{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:09:35Z","timestamp":1788329375586,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We evaluated the\n            <jats:italic>in vivo<\/jats:italic>\n            antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Schistosoma mansoni<\/jats:named-content>\n            , with total and female worm burden reductions of 80 and 90% (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05), respectively. Furthermore, treatment of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. haematobium<\/jats:named-content>\n            -infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.\n          <\/jats:p>","DOI":"10.1128\/aac.05371-11","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T07:21:24Z","timestamp":1321946484000},"page":"1090-1092","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["<i>In Vivo<\/i>\n            Activity of Aryl Ozonides against Schistosoma Species"],"prefix":"10.1128","volume":"56","author":[{"given":"Jennifer","family":"Keiser","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Ingram","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Chollet","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dong","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Vennerstrom","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00640-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1073\/pnas.1015762108","article-title":"Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria","volume":"108","author":"Charman SA","year":"2011","unstructured":"CharmanSA. 2011. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl. Acad. Sci. U. S. A. 108:4400\u20134405.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1021\/jm049040u","article-title":"Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes","volume":"48","author":"Dong Y","year":"2005","unstructured":"DongY. 2005. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J. Med. Chem. 48:4953\u20134961.","journal-title":"J. Med. Chem."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1016\/j.bmc.2006.05.041","article-title":"Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes","volume":"14","author":"Dong Y","year":"2006","unstructured":"DongY. 2006. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorg. Med. Chem. 14:6368\u20136382.","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1371\/journal.pntd.0000350","article-title":"Mefloquine-an aminoalcohol with promising antischistosomal properties in mice","volume":"3","author":"Keiser J","year":"2009","unstructured":"KeiserJ. 2009. Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLoS Negl. Trop. Dis. 3:e350.","journal-title":"PLoS Negl. Trop. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/jac\/dkr178","article-title":"Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro","volume":"66","author":"Keiser J","year":"2011","unstructured":"KeiserJ ManneckT VargasM. 2011. Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro. J. Antimicrob. Chemother. 66:1791\u20131797.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001285"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1517\/17460441.2.S1.S9","article-title":"Advances in the discovery and development of novel trematocidal drugs","volume":"2","author":"Keiser J","year":"2007","unstructured":"KeiserJ UtzingerJ. 2007. Advances in the discovery and development of novel trematocidal drugs. Expert Opin. Drug Discov. 2:9\u201323.","journal-title":"Expert Opin. Drug Discov."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/QCO.0b013e3282f19ec4","article-title":"Artemisinins and synthetic trioxolanes in the treatment of helminth infections","volume":"20","author":"Keiser J","year":"2007","unstructured":"KeiserJ UtzingerJ. 2007. Artemisinins and synthetic trioxolanes in the treatment of helminth infections. Curr. Opin. Infect. Dis. 20:605\u2013612.","journal-title":"Curr. Opin. Infect. Dis."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1473-3099(10)70161-4","article-title":"Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial","volume":"10","author":"Obonyo CO","year":"2010","unstructured":"ObonyoCO MuokEM MwinziPN. 2010. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial. Lancet Infect. Dis. 10:603\u2013611.","journal-title":"Lancet Infect. Dis."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00082-11"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1517\/17460441.2.S1.S53","article-title":"Schistosomes: challenges in drug screening","volume":"2","author":"Ramirez B","year":"2007","unstructured":"RamirezB. 2007. Schistosomes: challenges in drug screening. Expert Opin. Drug Discov. 2:53\u201361.","journal-title":"Expert Opin. Drug Discov."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1017\/S0031182009990552","article-title":"A wake up call for urinary schistosomiasis: reconciling research effort with public health importance","volume":"136","author":"Rollinson D","year":"2009","unstructured":"RollinsonD. 2009. A wake up call for urinary schistosomiasis: reconciling research effort with public health importance. Parasitology 136:1593\u20131610.","journal-title":"Parasitology"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.parint.2011.02.007","article-title":"Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89","volume":"60","author":"Taniguchi T","year":"2011","unstructured":"TaniguchiT. 2011. Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89. Parasitol. Int. 60:231\u2013236.","journal-title":"Parasitol. Int."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.actatropica.2010.08.020","article-title":"From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis","volume":"120","author":"Utzinger J","year":"2011","unstructured":"UtzingerJ N\u2032GoranKE CaffreyCR KeiserJ. 2011. From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop. 120(Suppl. 1):121\u2013137.","journal-title":"Acta Trop."},{"key":"e_1_3_2_18_2","unstructured":"VennerstromJL. May 2008. Spiro and dispiro 1 2 4-trioxolane antimalarials. US patent 7 371 778."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1016\/j.bmcl.2011.07.024","article-title":"The activity of dispiro peroxides against Fasciola hepatica","volume":"21","author":"Wang X","year":"2011","unstructured":"WangX. 2011. The activity of dispiro peroxides against Fasciola hepatica. Bioorg. Med. Chem. Lett. 21:5320\u20135323.","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01537-06"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.05371-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.05371-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:31:18Z","timestamp":1645482678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.05371-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1128\/AAC.05371-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.05371-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}