{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:55:57Z","timestamp":1769720157918,"version":"3.49.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e.,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Sporothrix schenckii<\/jats:named-content>\n            sensu stricto and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Sporothrix brasiliensis<\/jats:named-content>\n            , in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg\/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg\/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.\n          <\/jats:p>","DOI":"10.1128\/aac.05376-11","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T04:11:22Z","timestamp":1329192682000},"page":"2273-2277","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of Posaconazole in Murine Experimental Sporotrichosis"],"prefix":"10.1128","volume":"56","author":[{"given":"Fabiola","family":"Fern\u00e1ndez-Silva","sequence":"first","affiliation":[{"name":"Unitat d'Anatomia Patol\u00f2gica, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat d'Anatomia Patol\u00f2gica, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/516356"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02824.x"},{"key":"e_1_3_1_4_2","first-page":"443","article-title":"Disseminated sporotrichosis\u2014clinical case and discussion","volume":"14","author":"Barroso Pereira JC","year":"2008","unstructured":"Barroso PereiraJC. 2008. 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