{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:40:04Z","timestamp":1777426804622,"version":"3.51.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Primaquine is currently the only drug available for radical cure of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium vivax<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. ovale<\/jats:named-content>\n            liver infection stages, but limited safety data exist for children &lt;10 years of age. Detailed daily assessments of side effects in glucose-6-phosphate dehydrogenase (G6PD)-normal children treated with 14 days of primaquine plus chloroquine (3 days;\n            <jats:italic>n<\/jats:italic>\n            = 252) or artesunate (7 days;\n            <jats:italic>n<\/jats:italic>\n            = 141) (0.5 mg\/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age.\n          <\/jats:p>","DOI":"10.1128\/aac.05566-11","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T05:13:08Z","timestamp":1326863588000},"page":"2146-2149","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Tolerability and Safety of Primaquine in Papua New Guinean Children 1 to 10 Years of Age"],"prefix":"10.1128","volume":"56","author":[{"given":"Inoni","family":"Betuela","sequence":"first","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quique","family":"Bassat","sequence":"additional","affiliation":[{"name":"Barcelona Centre for International Health Research, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benson","family":"Kiniboro","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"Walter &amp; Eliza Hall Institute, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rosanas-Urgell","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"Barcelona Centre for International Health Research, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Stanisic","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"Walter &amp; Eliza Hall Institute, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Siba","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro L.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Barcelona Centre for International Health Research, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Mueller","sequence":"additional","affiliation":[{"name":"PNG Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"Barcelona Centre for International Health Research, Barcelona, Spain"},{"name":"Walter &amp; Eliza Hall Institute, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/424663"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1471-4922(03)00005-9","article-title":"Can primaquine therapy for vivax malaria be improved?","volume":"19","author":"Baird JK","year":"2003","unstructured":"BairdJK RieckmannKH. 2003. 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