{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:16:43Z","timestamp":1792167403009,"version":"4.4.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The carbapenemase NDM-1 has been identified recently in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>\n            as a source of multidrug resistance, including resistance to carbapenems. By analyzing the immediate genetic environment of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            carbapenemase gene among a series of NDM-1-producing enterobacterial isolates, a novel gene (\n            <jats:italic>ble<\/jats:italic>\n            <jats:sub>MBL<\/jats:sub>\n            , for\n            <jats:italic>ble<\/jats:italic>\n            gene associated with the metallo-\u03b2-lactamase NDM-1) was identified. The\n            <jats:italic>ble<\/jats:italic>\n            <jats:sub>MBL<\/jats:sub>\n            gene encodes a novel bleomycin resistance protein (BRP), named BRP\n            <jats:sub>MBL<\/jats:sub>\n            , that shares weak similarities with known BRPs (less than 60% amino acid identity). The expression of BRP\n            <jats:sub>MBL<\/jats:sub>\n            conferred resistance to bleomycin and to bleomycin-like molecules in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            . The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            and\n            <jats:italic>ble<\/jats:italic>\n            <jats:sub>MBL<\/jats:sub>\n            genes were coexpressed under the control of the same promoter, located upstream of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene and at the extremity of the insertion sequence IS\n            <jats:italic>Aba125<\/jats:italic>\n            . Most of the NDM producers possessed the\n            <jats:italic>ble<\/jats:italic>\n            <jats:sub>MBL<\/jats:sub>\n            gene. Although BRP\n            <jats:sub>MBL<\/jats:sub>\n            did not modify the growth or death rates of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            under experimental conditions, it suppressed the mutation rate of hypermutable\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            and therefore may stabilize the plasmid-borne\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene. This study suggests that the emerging carbapenemase NDM-1 is selected by bleomycin-like molecules, and that BRP\n            <jats:sub>MBL<\/jats:sub>\n            producers (and consequently NDM producers) are better suited to various environments.\n          <\/jats:p>","DOI":"10.1128\/aac.05583-11","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T07:59:10Z","timestamp":1327996750000},"page":"1693-1697","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":113,"title":["Association of the Emerging Carbapenemase NDM-1 with a Bleomycin Resistance Protein in Enterobacteriaceae and Acinetobacter baumannii"],"prefix":"10.1128","volume":"56","author":[{"given":"Laurent","family":"Dortet","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, K.-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.2042-7158.1990.tb06574.x","article-title":"Cytotoxic drugs and the aquatic environment: estimation of bleomycin in river and water samples","volume":"42","author":"Aherne GW","year":"1990","unstructured":"AherneGW HardcastleA NieldAH. 1990. 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