{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:07:19Z","timestamp":1791158839262,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            producing the highly virulent, multidrug-resistant, CTX-M-15 extended-spectrum \u03b2-lactamase (ESBL), sequence type 131 (ST131), has emerged on three continents since the late 2000s. We described the molecular epidemiology, clinical features, and outcome of ESBL-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            bacteremia in Taiwan from 2005 to 2010. This study aims to determine whether the risk factors, clinical features, and outcomes of the ST131 isolate differ from those of non-ST131 isolates. From 2005 to 2010, we collected 122 nonduplicated, consecutive, ESBL-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates from bloodstream infections in a 1,200-bed hospital in Taiwan. Isolates were characterized using multilocus sequence typing. Demographic data, clinical features, and outcomes were collected from medical chart records. Thirty-six (29.5%) patients with bacteremia with ESBL-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            ST131 were identified. Patients with clone ST131 were more likely to have secondary bacteremia and noncatheterized urinary tract infections (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). Secondary bacteremia (odds ratio [OR], 5.05; 95% confidence interval [CI], 1.08 to 23.56) and urinary catheter nonuse (OR, 3.77; 95% CI, 1.17 to 12.18) were independent risk factors for the ST131 clone after adjustment. Mortality rates at day 28 were similar in ST131 and non-ST131 populations. Independent risk factors predicting mortality at day 28 included malignancy, shock, and hospital-acquired bacteremia. In ESBL-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            bloodstream infections, the ST131 clone was not associated with health-care-associated risk factors, such as urinary catheter use or antibiotic exposure. Although highly virulent and multidrug resistant, the ST131 clone was not associated with higher mortality than non-ST131 clones.\n          <\/jats:p>","DOI":"10.1128\/aac.05753-11","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T02:31:59Z","timestamp":1322620319000},"page":"618-622","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Bacteremia Caused by Extended-Spectrum-\u03b2-Lactamase-Producing Escherichia coli Sequence Type ST131 and Non-ST131 Clones: Comparison of Demographic Data, Clinical Features, and Mortality"],"prefix":"10.1128","volume":"56","author":[{"given":"Hsing-Chun","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsu","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Nong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Haur","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Hsun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital\/I-Shou University, Kaohsiung County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1086\/340206","article-title":"Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection\u2014usp, iha, and iroN\n                  (E. coli)","volume":"185","author":"Bauer RJ","year":"2002","unstructured":"BauerRJ. 2002. Molecular epidemiology of 3 putative virulence genes for Escherichia coli urinary tract infection\u2014usp, iha, and iroN(E. coli). J. Infect. Dis. 185: 1521\u20131524.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl035"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4486-4491.2005"},{"key":"e_1_3_2_6_2","volume-title":"CLSI document M100-S18","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing: eighteenth informational supplement. CLSI document M100-S18. CLSI, Wayne, PA."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1402.070350"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp498"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq472"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.urology.2006.08.1075","article-title":"Epidemiology of urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli","volume":"68","author":"Ena J","year":"2006","unstructured":"EnaJ ArjonaF Martinez-PeinadoC Lopez-Perezagua MdelM AmadorC. 2006. Epidemiology of urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. Urology 68: 1169\u20131174.","journal-title":"Urology"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01361-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/653932"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijantimicag.2010.05.009","article-title":"Risk factors and treatment outcomes of community-onset bacteraemia caused by extended-spectrum beta-lactamase-producing Escherichia coli","volume":"36","author":"Kang CI","year":"2010","unstructured":"KangCI. 2010. Risk factors and treatment outcomes of community-onset bacteraemia caused by extended-spectrum beta-lactamase-producing Escherichia coli. Int. J. Antimicrob. Agents. 36: 284\u2013287.","journal-title":"Int. J. Antimicrob. 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