{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:58:53Z","timestamp":1762865933187},"reference-count":14,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Among 5,043 invasive pneumococcal disease (IPD) isolates identified through South African national surveillance from 2003 to 2007, we estimated the effect of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis on antimicrobial resistance. Patients on TMP-SMX prophylaxis were more likely to have a pneumococcal isolate nonsusceptible to TMP-SMX, penicillin, and rifampin. TMP-SMX nonsusceptibility was associated with nonsusceptibility to penicillin, erythromycin, and rifampin and multidrug resistance. This study informs empirical treatment of suspected IPD in patients with a history of TMP-SMX use.<\/jats:p>","DOI":"10.1128\/aac.05813-11","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T05:36:20Z","timestamp":1326173780000},"page":"1602-1605","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Trimethoprim-Sulfamethoxazole Prophylaxis and Antibiotic Nonsusceptibility in Invasive Pneumococcal Disease"],"prefix":"10.1128","volume":"56","author":[{"given":"Heidi M.","family":"Soeters","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"von Gottberg","sequence":"additional","affiliation":[{"name":"Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Cohen","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Quan","sequence":"additional","affiliation":[{"name":"National Microbiology Surveillance Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith P.","family":"Klugman","sequence":"additional","affiliation":[{"name":"Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"},{"name":"Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1463","article-title":"Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, C\u00f4te d'Ivoire: a randomised trial","volume":"353","author":"Anglaret X","year":"1999","unstructured":"AnglaretX. 1999. Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, C\u00f4te d'Ivoire: a randomised trial. Cotrimo-CI Study Group. Lancet 353:1463\u20131468.","journal-title":"Cotrimo-CI Study Group. Lancet"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/mdr.2006.12.169","article-title":"The role of antimicrobial use in the epidemiology of resistant pneumococci: a 10-year follow up","volume":"12","author":"Arason V","year":"2006","unstructured":"ArasonV SigurdssonJ ErlendsdottirH GudmundssonS KristinssonK. 2006. The role of antimicrobial use in the epidemiology of resistant pneumococci: a 10-year follow up. Microb. Drug Resist. 12:169\u2013176.","journal-title":"Microb. 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