{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:55:30Z","timestamp":1782140130562,"version":"3.54.5"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Clinical isolates of the\n Bacteroides fragilis<\/jats:named-content>\n group (\n n<\/jats:italic>\n = 387) were collected from patients attending nine Canadian hospitals in 2010-2011 and tested for susceptibility to 10 antimicrobial agents using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method.\n B. fragilis<\/jats:named-content>\n (59.9%),\n Bacteroides ovatus<\/jats:named-content>\n (16.3%), and\n Bacteroides thetaiotaomicron<\/jats:named-content>\n (12.7%) accounted for \u223c90% of isolates collected. Overall rates of percent susceptibility were as follows: 99.7%, metronidazole; 99.5%, piperacillin-tazobactam; 99.2%, imipenem; 97.7%, ertapenem; 92.0%, doripenem; 87.3%, amoxicillin-clavulanate; 80.9%, tigecycline; 65.9%, cefoxitin; 55.6%, moxifloxacin; and 52.2%, clindamycin. Percent susceptibility to cefoxitin, clindamycin, and moxifloxacin was lowest for\n B. thetaiotaomicron<\/jats:named-content>\n (\n n<\/jats:italic>\n = 49, 24.5%),\n Parabacteroides distasonis<\/jats:named-content>\n \/\n P. merdae<\/jats:named-content>\n (\n n<\/jats:italic>\n = 11, 9.1%), and\n B. ovatus<\/jats:named-content>\n (\n n<\/jats:italic>\n = 63, 31.8%), respectively. One isolate (\n B. thetaiotaomicron<\/jats:named-content>\n ) was resistant to metronidazole, and two isolates (both\n B. fragilis<\/jats:named-content>\n ) were resistant to both piperacillin-tazobactam and imipenem. Since the last published surveillance study describing Canadian isolates of\n B. fragilis<\/jats:named-content>\n group almost 20 years ago (A.-M. Bourgault et al., Antimicrob. Agents Chemother. 36:343\u2013347, 1992), rates of resistance have increased for amoxicillin-clavulanate, from 0.8% (1992) to 6.2% (2010-2011), and for clindamycin, from 9% (1992) to 34.1% (2010-2011).\n <\/jats:p>","DOI":"10.1128\/aac.05823-11","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T03:39:59Z","timestamp":1325043599000},"page":"1247-1252","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":96,"title":["Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis Group in Canada in 2010-2011: CANWARD Surveillance Study"],"prefix":"10.1128","volume":"56","author":[{"given":"James A.","family":"Karlowsky","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Walkty","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie R.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Hoban","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G.","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.5.798"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.2.343"},{"key":"e_1_3_2_4_2","unstructured":"Clinical and Laboratory Standards Institute. 2007. Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard seventh edition M11-A7. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_2_5_2","unstructured":"Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement vol. 31 no. 1. M100-S21. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.5.717"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinmicnews.2010.12.001","article-title":"Resistance trends in antimicrobial susceptibility of anaerobic bacteria, part I","volume":"33","author":"Goldstein EJC","year":"2011","unstructured":"GoldsteinEJC CitronDM. 2011. Resistance trends in antimicrobial susceptibility of anaerobic bacteria, part I. Clin. Microbiol. Newsl. 33:1\u20138.","journal-title":"Clin. Microbiol. 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National Committee for Clinical Laboratory Standards Wayne PA."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1086\/313805","article-title":"Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: finding of a multicenter prospective observational trial","volume":"30","author":"Nguyen MH","year":"2000","unstructured":"NguyenMH. 2000. Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: finding of a multicenter prospective observational trial. Clin. Infect. Dis. 30:870\u2013876.","journal-title":"Clin. Infect. 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