{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:26:21Z","timestamp":1772817981558,"version":"3.50.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Daptomycin-nonsusceptible (DNS)\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            strains have been reported over the last several years. Telavancin is a lipoglycopeptide with a dual mechanism of action, as it inhibits peptidoglycan polymerization\/cross-linking and disrupts the membrane potential. Three clinical DNS\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            strains, CB1814, R6212, and SA-684, were evaluated in an\n            <jats:italic>in vitro<\/jats:italic>\n            pharmacokinetic\/pharmacodynamic (PK\/PD) model with simulated endocardial vegetations (starting inoculum, 10\n            <jats:sup>8.5<\/jats:sup>\n            CFU\/g) for 120 h. Simulated regimens included telavancin at 10 mg\/kg every 24 h (q24h; peak, 87.5 mg\/liter;\n            <jats:italic>t<\/jats:italic>\n            <jats:sub>1\/2<\/jats:sub>\n            , 7.5 h), daptomycin at 6 mg\/kg q24h (peak, 95.7 mg\/liter;\n            <jats:italic>t<\/jats:italic>\n            <jats:sub>1\/2<\/jats:sub>\n            , 8 h), and vancomycin at 1 g q12h (peak, 30 mg\/liter;\n            <jats:italic>t<\/jats:italic>\n            <jats:sub>1\/2<\/jats:sub>\n            , 6 h). Differences in CFU\/g between regimens at 24 through 120 h were evaluated by analysis of variance with a Tukey's\n            <jats:italic>post hoc<\/jats:italic>\n            test. Bactericidal activity was defined as a \u22653-log\n            <jats:sub>10<\/jats:sub>\n            CFU\/g decrease in colony count from the initial inoculum. MIC values were 1, 0.25, and 0.5 mg\/liter (telavancin), 4, 2, and 2 mg\/liter (daptomycin), and 2, 2, and 2 mg\/liter (vancomycin) for CB1814, R6212, and SA-684, respectively. Telavancin displayed bactericidal activities against R6212 (32 to 120 h; \u22124.31 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/g), SA-684 (56 to 120 h; \u22123.06 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/g), and CB1814 (48 to 120 h; \u22124.9 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/g). Daptomycin displayed initial bactericidal activity followed by regrowth with all three strains. Vancomycin did not exhibit sustained bactericidal activity against any strain. At 120 h, telavancin was significantly better at reducing colony counts than vancomycin against all three tested strains and better than daptomycin against CB1814 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). Telavancin displayed bactericidal activity\n            <jats:italic>in vitro<\/jats:italic>\n            against DNS\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.05849-11","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T02:31:59Z","timestamp":1322620319000},"page":"955-959","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of Telavancin Activity versus Daptomycin and Vancomycin against Daptomycin-Nonsusceptible Staphylococcus aureus in an\n            <i>In Vitro<\/i>\n            Pharmacokinetic\/Pharmacodynamic Model"],"prefix":"10.1128","volume":"56","author":[{"given":"Molly E.","family":"Steed","sequence":"first","affiliation":[{"name":"Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Vidaillac","sequence":"additional","affiliation":[{"name":"Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rybak","sequence":"additional","affiliation":[{"name":"Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Michigan, USA"},{"name":"School of Medicine, Wayne State University, Michigan, USA"},{"name":"Detroit Receiving Hospital Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.454-459.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.7.1925-1929.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00247-06"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/520655"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3960-3963.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0732-8893(03)00119-6","article-title":"Daptomycin against multiple drug-resistant staphylococcus and enterococcus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations","volume":"47","author":"Cha R","year":"2003","unstructured":"ChaR RybakMJ. 2003. Daptomycin against multiple drug-resistant staphylococcus and enterococcus isolates in an in vitro pharmacodynamic model with simulated endocardial vegetations. Diagn. Microbiol. Infect. Dis. 47: 539\u2013546.","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_8_2","unstructured":"Clinical Laboratory Standards Institute. 2008. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 8th ed.  Approved standard M7-A8. 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