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This study compared the<jats:italic>in vitro<\/jats:italic>activity of tigecycline against 3,014 isolates of clinically important drug-resistant bacteria using the standard broth microdilution and disk diffusion methods. Species studied included methicillin-resistant<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>(MRSA;<jats:italic>n<\/jats:italic>= 759), vancomycin-resistant<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterococcus faecium<\/jats:named-content>(VRE;<jats:italic>n<\/jats:italic>= 191), extended-spectrum \u03b2-lactamase (ESBL)-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 602), ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 736), and<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 726) that had been collected from patients treated between 2008 and 2010 at 20 hospitals in Taiwan. MICs and inhibition zone diameters were interpreted according to the currently recommended U.S. Food and Drug Administration (FDA) criteria and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria. The MIC<jats:sub>90<\/jats:sub>values of tigecycline against MRSA, VRE, ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>, ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>, and<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>were 0.5, 0.125, 0.5, 2, and 8 \u03bcg\/ml, respectively. The total error rates between the two methods using the FDA criteria were high: 38.4% for ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>and 33.8% for<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>. Using the EUCAST criteria, the total error rate was also high (54.6%) for<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>isolates. The total error rates between these two methods were &lt;5% for MRSA, VRE, and ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>. For routine susceptibility testing of ESBL-producing<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">K. pneumoniae<\/jats:named-content>and<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>against tigecycline, the broth microdilution method should be used because of the poor correlation of results between these two methods.<\/jats:p>","DOI":"10.1128\/aac.05879-11","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T05:21:18Z","timestamp":1323753678000},"page":"1414-1417","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Agreement Assessment of Tigecycline Susceptibilities Determined by the Disk Diffusion and Broth Microdilution Methods among Commonly Encountered Resistant Bacterial Isolates: Results from the Tigecycline<i>In Vitro<\/i>Surveillance in Taiwan (TIST) Study, 2008 to 2010"],"prefix":"10.1128","volume":"56","author":[{"given":"Jien-Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University Medical College, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsing","family":"Liao","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Te","family":"Lu","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Lotung Poh-Ai Hospital, Lotung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ming","family":"Tsao","sequence":"additional","affiliation":[{"name":"Infectious Section, Internal Medicine Department, Institute of Microbiology and Immunology, Chung Shan Medical University and University Hospital, 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