{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:38:53Z","timestamp":1792633133788,"version":"4.5.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Since the separation of\n Pseudallescheria boydii<\/jats:named-content>\n and\n P. apiosperma<\/jats:named-content>\n in 2010, limited data on species-specific susceptibility patterns of these and other species of\n Pseudallescheria<\/jats:named-content>\n and its anamorph\n Scedosporium<\/jats:named-content>\n have been reported. This study presents the antifungal susceptibility patterns of members affiliated with both entities. Clinical and environmental isolates (\n n<\/jats:italic>\n = 332) from a wide range of sources and origins were identified down to species level and tested according to CLSI M38-A2 against eight antifungal compounds. Whereas\n P. apiosperma<\/jats:named-content>\n (geometric mean MIC\/minimal effective concentration [MEC] values of 0.9, 2.4, 7.4, 16.2, 0.2, 0.8, 1.5, and 6.8 \u03bcg\/ml for voriconazole, posaconazole, isavuconazole, itraconazole, micafungin, anidulafungin, caspofungin, and amphotericin B, respectively) and\n P. boydii<\/jats:named-content>\n (geometric mean MIC\/MEC values of 0.7, 1.3, 5.7, 13.8, 0.5, 1.4, 2.3, and 11.8 \u03bcg\/ml for voriconazole, posaconazole, isavuconazole, itraconazole, micafungin, anidulafungin, caspofungin, and amphotericin B, respectively) had similar susceptibility patterns, those for\n S. aurantiacum<\/jats:named-content>\n ,\n S. prolificans<\/jats:named-content>\n , and\n S. dehoogii<\/jats:named-content>\n were different from each other. Voriconazole was the only drug with significant activity against\n S. aurantiacum<\/jats:named-content>\n isolates. The MIC distributions of all drugs except voriconazole did not show a normal distribution and often showed two subpopulations, making a species-based prediction of antifungal susceptibility difficult. Therefore, antifungal susceptibility testing of all clinical isolates remains essential for targeted antifungal therapy. Voriconazole was the only compound with low MIC values (MIC\n 90<\/jats:sub>\n of \u22642 \u03bcg\/ml) for\n P. apiosperma<\/jats:named-content>\n and\n P. boydii<\/jats:named-content>\n . Micafungin and posaconazole showed moderate activity against the majority of\n Scedosporium<\/jats:named-content>\n strains.\n <\/jats:p>","DOI":"10.1128\/aac.05910-11","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T02:59:10Z","timestamp":1327978750000},"page":"2635-2642","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":283,"title":["Species-Specific Antifungal Susceptibility Patterns of Scedosporium and Pseudallescheria Species"],"prefix":"10.1128","volume":"56","author":[{"given":"Michaela","family":"Lackner","sequence":"first","affiliation":[{"name":"Federal Institute for Drugs and Medical Devices Biosafety Laboratory, Bonn, Germany"},{"name":"Institute of Microbiology, University of Innsbruck, Innsbruck, Austria"},{"name":"Innsbruck Medical University, Division of Hygiene and Medical Microbiology, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"KNAW Fungal Biodiversity Centre (CBS), Utrecht, Netherlands"},{"name":"Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad J.","family":"Najafzadeh","sequence":"additional","affiliation":[{"name":"KNAW Fungal Biodiversity Centre (CBS), Utrecht, Netherlands"},{"name":"Department of Parasitology and Mycology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Curfs-Breuker","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corn\u00e9 H.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands"},{"name":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01177-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/00365540600786564","article-title":"Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine","volume":"39","author":"Bhat SV","year":"2007","unstructured":"BhatSV PatersonDL RinaldiMG VeldkampPJ. 2007. 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