{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:53:32Z","timestamp":1760385212157},"reference-count":10,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The enterococcal plasmid pKQ10 has been reported to carry a poorly characterized tetracycline resistance determinant designated\n            <jats:italic>tet<\/jats:italic>\n            (U). However, in a series of studies intended to further characterize this determinant, we have been unable to substantiate the claim that\n            <jats:italic>tet<\/jats:italic>\n            (U) confers resistance to tetracyclines. In line with these results, bioinformatic analysis provides compelling evidence that \u201c\n            <jats:italic>tet<\/jats:italic>\n            (U)\u201d is in fact the misannotated 3\u2032 end of a gene encoding a rolling-circle replication initiator (Rep) protein.\n          <\/jats:p>","DOI":"10.1128\/aac.05957-11","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:42:02Z","timestamp":1334018522000},"page":"3378-3379","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["\u201c\n            <i>tet<\/i>\n            (U)\u201d Is Not a Tetracycline Resistance Determinant"],"prefix":"10.1128","volume":"56","author":[{"given":"Jamie A.","family":"Caryl","sequence":"first","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Cox","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Trimble","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex J.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)49928-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-008-9266-x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.61.4.442-455.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/plas.1996.0009","article-title":"A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium","volume":"35","author":"Ridenhour MB","year":"1996","unstructured":"RidenhourMB FletcherHM MortensenJE Daneo-MooreL. 1996. A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium. Plasmid 35:71\u201380.","journal-title":"Plasmid"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.02.034"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2005.01.016"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0172-6"},{"key":"e_1_3_2_9_2","first-page":"141","article-title":"Replication of staphylococcal plasmid pC221: molecular mechanism of initiator protein activity. 4","volume":"41","author":"Thomas CD","year":"1999","unstructured":"ThomasCD DavyCE JenningsLJ PapadopoulosF. 1999. Replication of staphylococcal plasmid pC221: molecular mechanism of initiator protein activity. 4. Plasmid 41:141\u2013177.","journal-title":"Plasmid"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-239"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00576-06"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.05957-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.05957-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:04:32Z","timestamp":1645481072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.05957-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1128\/AAC.05957-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.05957-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"2011-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}