{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:55:08Z","timestamp":1770821708001,"version":"3.50.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n The Tigecycline\n In Vitro<\/jats:italic>\n Surveillance in Taiwan (TIST) study, a nationwide, prospective surveillance during 2006 to 2010, collected a total of 7,793 clinical isolates, including methicillin-resistant\n Staphylococcus aureus<\/jats:named-content>\n (MRSA) (\n n<\/jats:italic>\n = 1,834), penicillin-resistant\n Streptococcus pneumoniae<\/jats:named-content>\n (PRSP) (\n n<\/jats:italic>\n = 423), vancomycin-resistant enterococci (VRE) (\n n<\/jats:italic>\n = 219), extended-spectrum \u03b2-lactamase (ESBL)-producing\n Escherichia coli<\/jats:named-content>\n (\n n<\/jats:italic>\n = 1,141), ESBL-producing\n Klebsiella pneumoniae<\/jats:named-content>\n (\n n<\/jats:italic>\n = 1,330),\n Acinetobacter baumannii<\/jats:named-content>\n (\n n<\/jats:italic>\n = 1,645), and\n Stenotrophomonas maltophilia<\/jats:named-content>\n (\n n<\/jats:italic>\n = 903), from different specimens from 20 different hospitals in Taiwan. MICs of tigecycline were determined following the criteria of the U.S. Food and Drug Administration (FDA) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST-2011). Among drug-resistant Gram-positive pathogens, all of the PRSP isolates were susceptible to tigecycline (MIC\n 90<\/jats:sub>\n , 0.03 \u03bcg\/ml), and only one MRSA isolate (MIC\n 90<\/jats:sub>\n , 0.5 \u03bcg\/ml) and three VRE isolates (MIC\n 90<\/jats:sub>\n , 0.125 \u03bcg\/ml) were nonsusceptible to tigecycline. Among the Gram-negative bacteria, the tigecycline susceptibility rates were 99.65% for ESBL-producing\n E. coli<\/jats:named-content>\n (MIC\n 90<\/jats:sub>\n , 0.5 \u03bcg\/ml) and 96.32% for ESBL-producing\n K. pneumoniae<\/jats:named-content>\n (MIC\n 90<\/jats:sub>\n , 2 \u03bcg\/ml) when interpreted by FDA criteria but were 98.7% and 85.8%, respectively, when interpreted by EUCAST-2011 criteria. The susceptibility rate for\n A. baumannii<\/jats:named-content>\n (MIC\n 90<\/jats:sub>\n , 4 \u03bcg\/ml) decreased from 80.9% in 2006 to 55.3% in 2009 but increased to 73.4% in 2010. A bimodal MIC distribution was found among carbapenem-susceptible\n A. baumannii<\/jats:named-content>\n isolates, and a unimodal MIC distribution was found among carbapenem-nonsusceptible\n A. baumannii<\/jats:named-content>\n isolates. In Taiwan, tigecycline continues to have excellent\n in vitro<\/jats:italic>\n activity against several major clinically important drug-resistant bacteria, with the exception of\n A. baumannii<\/jats:named-content>\n .\n <\/jats:p>","DOI":"10.1128\/aac.06053-11","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T03:39:59Z","timestamp":1325043599000},"page":"1452-1457","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Trends in the Susceptibility of Clinically Important Resistant Bacteria to Tigecycline: Results from the Tigecycline\n In Vitro<\/i>\n Surveillance in Taiwan Study, 2006 to 2010"],"prefix":"10.1128","volume":"56","author":[{"given":"Yen-Hsu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsing","family":"Liao","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Te","family":"Lu","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Lotung Poh-Ai Hospital, Yilan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ming","family":"Tsao","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Institute of Microbiology and Immunology, Chung Shan Medical University and University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Shen","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Shuang Ho Hospital, Tapei Medical University and School of Medicine, Taipei Medical University, Taipei, and Section of Infectious Diseases, Departement of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Ching","family":"Liu","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Shuang Ho Hospital, Tapei Medical University and School of Medicine, Taipei Medical University, Taipei, and Section of Infectious Diseases, Departement of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsrang-Neng","family":"Jang","sequence":"additional","affiliation":[{"name":"Section of Infectious 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Ching","family":"Pan","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch and Department of Internal Medicine, National Taiwan University Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch and Department of Internal Medicine, National Taiwan University Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Chi","family":"Kung","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch and Department of Internal Medicine, National Taiwan University Hospital, Yunlin, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Eng","family":"Liu","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jien-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung Medical College, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Infection Control, 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