{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:35:08Z","timestamp":1788226508558,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            There is little information about the effectiveness of ciprofloxacin in regions where ciprofloxacin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            is prevalent. This study was conducted to evaluate whether ciprofloxacin is effective as the initial empirical antibiotic for treatment of uncomplicated acute pyelonephritis (APN) due to ciprofloxacin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            . A total of 255 women with clinical diagnoses of uncomplicated APN due to\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            were enrolled in the emergency department between March 2005 and December 2008. All enrolled patients were initially treated with ciprofloxacin. Patients were followed up 4 to 7 days after the start of therapy and 14 to 21 days after its completion. At the first follow-up visit, ciprofloxacin was changed to the appropriate antibiotic when necessary, depending on the antibiotic susceptibility results. Not only improvement of symptoms and signs but also microbiologic eradication was assessed at each visit. Fifteen percent (39\/255) of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            isolates were resistant to ciprofloxacin. There was no statistically significant difference between the clinical cure rates of the ciprofloxacin-susceptible group and the ciprofloxacin-resistant group at the first follow-up (87.0% versus 76.9%,\n            <jats:italic>P<\/jats:italic>\n            = 0.135) or the second follow-up (98.6% versus 94.9%,\n            <jats:italic>P<\/jats:italic>\n            = 0.177). However, there was a lower microbiologic cure rate in the ciprofloxacin-resistant group than in the ciprofloxacin-susceptible group (92.4% versus 41.7%,\n            <jats:italic>P<\/jats:italic>\n            = 0.000) at the first follow-up visit. No complications occurred in the ciprofloxacin-resistant group during the follow-up period. Our findings indicate that ciprofloxacin is an appropriate choice for empirical therapy of uncomplicated APN and has no serious adverse outcomes, if it is tailored appropriately, even for women infected with ciprofloxacin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">E. coli<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.06212-11","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T05:49:51Z","timestamp":1331012991000},"page":"3043-3046","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Empirical Use of Ciprofloxacin for Acute Uncomplicated Pyelonephritis Caused by Escherichia coli in Communities Where the Prevalence of Fluoroquinolone Resistance Is High"],"prefix":"10.1128","volume":"56","author":[{"given":"Jae Hyun","family":"Jeon","sequence":"first","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuseok","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Dae","family":"Han","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Un","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Eui","family":"Rhee","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Ho","family":"Song","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eu Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung-don","family":"Oh","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"},{"name":"Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1086\/340616","article-title":"Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization","volume":"34","author":"Blot S","year":"2002","unstructured":"BlotS VandewoudeK De BacquerD ColardynF. 2002. Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin. Infect. Dis. 34:1600\u20131606.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_3_2","volume-title":"Approved standard M100-S15","author":"Clinical and Laboratory Standards Institute","year":"2005","unstructured":"Clinical and Laboratory Standards Institute. 2005. Performance standards for antimicrobial disk susceptibility testing: 15th informational supplement, vol 25. Approved standard M100-S15. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030027"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-1-200107030-00012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.07.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.12.1375"},{"key":"e_1_3_2_9_2","first-page":"957","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Jack DS","year":"2010","unstructured":"JackDS KayeD. 2010. Urinary tract infection, p 957\u2013985. In MandellGL BennettJE DolinR (ed), Mandell, Douglas, and Bennett's principles and practice of infectious diseases, 7th ed. 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