{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:52:51Z","timestamp":1789768371686,"version":"4.0.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n In published studies, cohorts of patients with bacteremia due to vancomycin-resistant\n Enterococcus<\/jats:named-content>\n (VRE) have predominantly been infected with\n Enterococcus faecium<\/jats:named-content>\n . Little is known about the epidemiology and outcomes associated with bacteremia due to VR\n Enterococcus faecalis<\/jats:named-content>\n . A retrospective study of isolates obtained from January 2008 to October 2010 was conducted at Detroit Medical Center (DMC). Unique patients with blood cultures positive for VRE were reviewed. Outcomes were analyzed using logistic regression. During the study period, 105 cases of bacteremia due to VR\n E. faecalis<\/jats:named-content>\n and 197 cases of bacteremia due to VR\n E. faecium<\/jats:named-content>\n were identified. The mean age in the study cohort was 61.5 \u00b1 15 years; 162 subjects (53.6%) were male. After controlling for a propensity score, bacteremia due to VR\n E. faecalis<\/jats:named-content>\n was associated with >2-fold-lower in-hospital mortality than bacteremia due to VR\n E. faecium<\/jats:named-content>\n . Interestingly, bacteremia due to VR\n E. faecalis<\/jats:named-content>\n was associated with longer hospital stay after VRE isolation, although total length of stay was similar for groups with VR\n E. faecalis<\/jats:named-content>\n and VR\n E. faecium<\/jats:named-content>\n . Bacteremia due to VR\n E. faecalis<\/jats:named-content>\n was associated with a >2-fold-lower risk for mortality than bacteremia due to VR\n E. faecium<\/jats:named-content>\n , possibly due to the availability of \u03b2-lactam therapeutics for treatment of VR\n E. faecalis<\/jats:named-content>\n .\n <\/jats:p>","DOI":"10.1128\/aac.06299-11","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T02:37:05Z","timestamp":1329878225000},"page":"2452-2458","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Comparison of the Clinical Characteristics and Outcomes Associated with Vancomycin-Resistant Enterococcus faecalis and Vancomycin-Resistant E. faecium Bacteremia"],"prefix":"10.1128","volume":"56","author":[{"given":"Kayoko","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Marchaim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Yousuf","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, 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