{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:49:32Z","timestamp":1771008572285,"version":"3.50.1"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            activities of LFF571, a novel analog of GE2270A that inhibits bacterial growth by binding with high affinity for protein synthesis elongation factor Tu, fidaxomicin, and 10 other antimicrobial agents were determined against 50 strains of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium difficile<\/jats:named-content>\n            and 630 other anaerobic and aerobic organisms of intestinal origin. LFF571 possesses potent activity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. difficile<\/jats:named-content>\n            and most other Gram-positive anaerobes (MIC\n            <jats:sub>90<\/jats:sub>\n            , \u22640.25 \u03bcg\/ml), with the exception of bifidobacteria and lactobacilli. The MIC\n            <jats:sub>90<\/jats:sub>\n            s for aerobes, including enterococci,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            (as well as methicillin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            [MRSA] isolates),\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Streptococcus pyogenes<\/jats:named-content>\n            , and other streptococci were 0.06, 0.125, 2, and 8 \u03bcg\/ml, respectively. Comparatively, fidaxomicin showed variable activity against Gram-positive organisms: MIC\n            <jats:sub>90<\/jats:sub>\n            s against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. difficile<\/jats:named-content>\n            ,\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium perfringens<\/jats:named-content>\n            , and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bifidobacterium<\/jats:named-content>\n            spp. were 0.5, \u22640.015, and 0.125 \u03bcg\/ml, respectively, but &gt;32 \u03bcg\/ml against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium ramosum<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Clostridium innocuum<\/jats:named-content>\n            . MIC\n            <jats:sub>90<\/jats:sub>\n            for\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. pyogenes<\/jats:named-content>\n            and other streptococci was 16 and &gt;32 \u03bcg\/ml, respectively. LFF571 and fidaxomicin were generally less active against Gram-negative anaerobes.\n          <\/jats:p>","DOI":"10.1128\/aac.06305-11","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T07:59:10Z","timestamp":1327996750000},"page":"2493-2503","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Comparative\n            <i>In Vitro<\/i>\n            Activities of LFF571 against Clostridium difficile and 630 Other Intestinal Strains of Aerobic and Anaerobic Bacteria"],"prefix":"10.1128","volume":"56","author":[{"given":"Diane M.","family":"Citron","sequence":"first","affiliation":[{"name":"R. M. Alden Research Lab, Culver City, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerin L.","family":"Tyrrell","sequence":"additional","affiliation":[{"name":"R. M. 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