{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:47:19Z","timestamp":1758905239476},"reference-count":12,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We studied the penetration of etravirine and HIV shedding in the genital tract among 12 HIV-1-infected women receiving an etravirine-containing regimen who had &lt;40 copies\/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median etravirine concentrations were 663 ng\/ml in BP and 857 ng\/ml in CVF, with a CVF\/BP etravirine ratio of approximately 1.2. This good penetration of etravirine may contribute to the control of viral replication in the female genital tract.<\/jats:p>","DOI":"10.1128\/aac.06474-11","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T05:01:18Z","timestamp":1335243678000},"page":"4018-4020","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Etravirine Concentrations in the Cervicovaginal Compartment in HIV-1-Infected Women Receiving Etravirine-Containing Antiretroviral Therapy: DIVA 02 Study"],"prefix":"10.1128","volume":"56","author":[{"given":"C.","family":"Clavel","sequence":"first","affiliation":[{"name":"LC Fleming Hospital, Infectious Diseases, Saint Martin, French West Indies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Peytavin","sequence":"additional","affiliation":[{"name":"Bichat-Claude Bernard Hospital, Pharmacology, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tubiana","sequence":"additional","affiliation":[{"name":"Piti\u00e9 Salp\u00e9tri\u00e8re Hospital APHP and INSERM U943, Infectious Diseases, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Souli\u00e9","sequence":"additional","affiliation":[{"name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital APHP and INSERM U943, Virology, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Courbon","sequence":"additional","affiliation":[{"name":"Bichat-Claude Bernard Hospital, Pharmacology, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Crenn-Hebert","sequence":"additional","affiliation":[{"name":"Louis Mourier Hospital APHP, Obstetrics-Gynecology, Colombes, and Paris-Diderot University, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ichou","sequence":"additional","affiliation":[{"name":"Louis Mourier Hospital, Virology, Colombes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Blanc","sequence":"additional","affiliation":[{"name":"Piti\u00e9 Salp\u00e9tri\u00e8re Hospital APHP and INSERM U943, Infectious Diseases, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Piti\u00e9 Salp\u00e9tri\u00e8re Hospital APHP and INSERM U943, Infectious Diseases, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Katlama","sequence":"additional","affiliation":[{"name":"Piti\u00e9 Salp\u00e9tri\u00e8re Hospital APHP and INSERM U943, Infectious Diseases, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-G.","family":"Marcelin","sequence":"additional","affiliation":[{"name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital APHP and INSERM U943, Virology, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Louis Mourier Hospital APHP, Obstetrics-Gynecology, Colombes, and Paris-Diderot University, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01460-10"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1097\/QAD.0b013e32833e5043","article-title":"Genital tract HIV-1 RNA shedding among women with below detectable plasma viral load","volume":"24","author":"Cu-Uvin S","year":"2010","unstructured":"Cu-UvinS . 2010. 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