{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T12:40:59Z","timestamp":1648989659306},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1972,2,1]],"date-time":"1972-02-01T00:00:00Z","timestamp":65750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1972,2]]},"abstract":"<jats:p>\n            The\n            <jats:italic>Enterobacter<\/jats:italic>\n            species\n            <jats:italic>E. aerogenes, E. cloacae<\/jats:italic>\n            , and\n            <jats:italic>E. hafnia<\/jats:italic>\n            were examined for resistance to penicillin and cephalosporin derivatives. All were resistant to benzyl penicillin, ampicillin, 6 [\n            <jats:sc>d<\/jats:sc>\n            (\u2212)\u03b1-amino-\n            <jats:italic>p<\/jats:italic>\n            -hydroxyphenylacetamido] penicillanic acid, cephaloridine, cephalothin, and cephalexin. A significant number were sensitive to carbenicillin and 6 [\n            <jats:sc>d<\/jats:sc>\n            (\u2212)\u03b1-carboxy-3-thienylacetamido] penicillanic acid. No differences among the three species were noted. The \u03b2-lactamase activity was cell-bound, and was not released by osmotic shock, toluene treatment, or diphenylamine treatment. It was rarely released into the growth medium. The \u03b2-lactamase activity was primarily directed against cephalosporin derivatives. Synthesis of \u03b2-lactamase was chromosomally mediated. Resistance to ampicillin seemed to be partly related to entry of the molecule into the bacteria since exposure to ethylenediaminetetraacetate lowered the minimal inhibitory concentration.\n          <\/jats:p>","DOI":"10.1128\/aac.1.2.107","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"107-111","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Relation of \u03b2-Lactamase Activity and Cellular Location to Resistance of\n            <i>Enterobacter<\/i>\n            to Penicillins and Cephalosporins"],"prefix":"10.1128","volume":"1","author":[{"given":"Harold C.","family":"Neu","sequence":"first","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine B.","family":"Winshell","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.1.2.107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.1.2.107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:05:45Z","timestamp":1645484745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.1.2.107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,2]]}},"alternative-id":["10.1128\/AAC.1.2.107"],"URL":"https:\/\/doi.org\/10.1128\/aac.1.2.107","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,2]]},"assertion":[{"value":"1972-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}