{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:50:21Z","timestamp":1791283821959,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1976,7,1]],"date-time":"1976-07-01T00:00:00Z","timestamp":205027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1976,7]]},"abstract":"<jats:p>\n            A diverse group of anaerobic bacteria representing a spectrum of resistance to \u03b2-lactam antibiotics was studied to characterize their \u03b2-lactamase activity and relate it to resistance. The\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            organisms had moderate resistance and produced a cephalosporinase with low activity. The\n            <jats:italic>Clostridium ramosum<\/jats:italic>\n            was intermediate in resistance and had intermediate, inducible \u03b2-lactamase activity. The\n            <jats:italic>B. clostridiiformis<\/jats:italic>\n            organism was highly resistant, produced a potent inducible penicillinase, and had a barrier to the penicillin substrates. Only the \u03b2-lactamase of\n            <jats:italic>C. ramosum<\/jats:italic>\n            fit Richmond's classification (class IV). Although there was a rough correlation between \u03b2-lactamase activity and antibiotic resistance, other mechanisms are undoubtedly involved in determining resistance levels.\n          <\/jats:p>","DOI":"10.1128\/aac.10.1.106","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Beta-Lactamase Activity in Anaerobic Bacteria"],"prefix":"10.1128","volume":"10","author":[{"given":"A. Elise","family":"Weinrich","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Immunology, Medical University of South Carolina, Charleston, South Carolina 29401"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E. Del","family":"Bene","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Immunology, Medical University of South Carolina, Charleston, South Carolina 29401"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.10.1.106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.10.1.106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:35:14Z","timestamp":1645450514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.10.1.106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,7]]}},"alternative-id":["10.1128\/AAC.10.1.106"],"URL":"https:\/\/doi.org\/10.1128\/aac.10.1.106","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,7]]},"assertion":[{"value":"1976-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}