{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:40:58Z","timestamp":1648824058071},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:p>\n            Pirbenicillin, a semisynthetic penicillin, showed greater in vitro activity against 68 recent isolates of\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            than did ticarcillin or carbenicillin. The median minimum inhibitory concentration of each of these three compounds, respectively, was 3.1, 12.5, and 25 \u03bcg\/ml when a 10\n            <jats:sup>\u22124<\/jats:sup>\n            dilution of an overnight culture (about 10\n            <jats:sup>5<\/jats:sup>\n            colony-forming units [CFU]\/ml) was used as inoculum, but these differences were less striking when larger inocula were used: at 10\n            <jats:sup>7<\/jats:sup>\n            CFU\/ml these values were 6.25, 12.5, and 50 \u03bcg\/ml, and at 10\n            <jats:sup>8<\/jats:sup>\n            to 10\n            <jats:sup>9<\/jats:sup>\n            CFU\/ml these values were 50, 50, and 100 \u03bcg\/ml. All three compounds showed greater inhibitory activity at pH 6 than at pH 8. This pH effect was greatest with pirbenicillin, for 6.25 \u03bcg of pirbenicillin per ml inhibited 7, 11, and 57% of the strains at pH 6, 7, and 8, respectively; these values were 4, 4, and 11% with ticarcillin and 0, 0, and 7% with carbenicillin. At sufficient inhibitory concentrations, the rates of bacterial killing of the three compounds were similar. The observed differences in anti-pseudomonad activity were not due to differences in stability to pseudomonad \u03b2-lactamases, but all three compounds were more stable than were cefazolin, cephaloridine, and benzylpenicillin.\n          <\/jats:p>","DOI":"10.1128\/aac.11.1.1","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"1-6","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Comparative In Vitro Activity of Pirbenicillin, Ticarcillin, and Carbenicillin Against\n            <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"11","author":[{"given":"Takeo","family":"Murakawa","sequence":"first","affiliation":[{"name":"Section on Infectious Diseases, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. D.","family":"Sabath","sequence":"additional","affiliation":[{"name":"Section on Infectious Diseases, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.1.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.1.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:53:21Z","timestamp":1645451601000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.11.1.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1128\/AAC.11.1.1"],"URL":"https:\/\/doi.org\/10.1128\/aac.11.1.1","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]},"assertion":[{"value":"1977-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}