{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:51:33Z","timestamp":1773874293224,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1977,3,1]],"date-time":"1977-03-01T00:00:00Z","timestamp":226022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:p>\n            The patterns of drug resistance and the frequency of conjugative R plasmids in intestinal\n            <jats:italic>Escherichia coli<\/jats:italic>\n            from 88 patients treated for a skin disease (\n            <jats:italic>acne vulgaris<\/jats:italic>\n            ) with low oral doses of tetracycline are reported. The proportion of patients with resistant bacteria was progressively greater in patients who received tetracycline for 1 week, 4 weeks, or longer (from 50 to 88%). No multiply drug-resistant bacteria were detected before treatment or after 1 week of treatment. After more than 4 weeks of treatment, multiply drug-resistant\n            <jats:italic>E. coli<\/jats:italic>\n            were isolated from about 50% of the patients. The origin and selection of R plasmid-determined multiple drug resistance are discussed.\n          <\/jats:p>","DOI":"10.1128\/aac.11.3.388","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"388-391","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy"],"prefix":"10.1128","volume":"11","author":[{"given":"J. K.","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Bartholin Building, University of Aarhus, Dk-8000 Aarhus C, Denmark,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Leth","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stenderup","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Afzelius","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.3.388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.3.388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:54:56Z","timestamp":1645451696000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.11.3.388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["10.1128\/AAC.11.3.388"],"URL":"https:\/\/doi.org\/10.1128\/aac.11.3.388","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]},"assertion":[{"value":"1977-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}