{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T14:03:27Z","timestamp":1648562607544},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1977,6,1]],"date-time":"1977-06-01T00:00:00Z","timestamp":233971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:p>\n            A plasmid-specified, inducible, but cyclic adenylic acid (cAMP)-independent resistance to chloramphenicol (CM) is reported. The resistance level to CM was increased two- to fourfold by treatment with a small amount of CM for a short period in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            strains carrying the R plasmid pJY1, which was obtained from a clinical isolate of\n            <jats:italic>Vibrio cholerae<\/jats:italic>\n            . Though cAMP was required for production of CM acetyltransferase (CATase) in cAMP-deficient mutants of\n            <jats:italic>E. coli<\/jats:italic>\n            carrying the R100 plasmid, the same species harboring pJY1 did not require cAMP for production of the enzyme. The possibility of a mechanism other than CATase activity for the CM resistance conferred by R plasmids is discussed.\n          <\/jats:p>","DOI":"10.1128\/aac.11.6.952","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"952-955","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Cyclic Adenylic Acid-Dependent and -Independent Production of Chloramphenicol Acetyltransferase in\n            <i>Escherichia coli<\/i>\n            Carrying R Plasmids"],"prefix":"10.1128","volume":"11","author":[{"given":"Takeshi","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Bacteriology, School of Medicine, Juntendo University, Toyko 113"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, School of Medicine, Juntendo University, Toyko 113"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiko","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, School of Medicine, Juntendo University, Toyko 113"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Toho University, Tokyo 143, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.6.952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.11.6.952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:39Z","timestamp":1645485279000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.11.6.952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1977,6]]}},"alternative-id":["10.1128\/AAC.11.6.952"],"URL":"https:\/\/doi.org\/10.1128\/aac.11.6.952","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6]]},"assertion":[{"value":"1977-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}