{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:45:12Z","timestamp":1756993512956},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>\n            Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strains, the order of activity observed was: BL-P1654 &gt; penicillin X &gt; penicillin G &gt; ampicillin &gt; amoxicillin = carbenicillin. MICs against strains isolated from women with gonococcal pelvic inflammatory disease were significantly higher than those against isolates from uncomplicated infections: BL-P1654,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001; penicillin X,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001; penicillin G,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001; ampicillin,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001; and amoxicillin,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05. MICs of penicillin G were \u22650.125 \u03bcg\/ml against 33 (36%) of the 92 strains from patients with uncomplicated infections, as contrasted with 15 (68%) of the 22 isolates from women with pelvic inflammatory disease (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01). The means of the MICs of penicillin G were 0.06 \u03bcg\/ml for the former and 0.14 \u03bcg\/ml for the latter.\n          <\/jats:p>","DOI":"10.1128\/aac.12.1.31","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"31-36","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["In Vitro Activity of\n            <i>p<\/i>\n            -Hydroxybenzyl Penicillin (Penicillin X) and Five Other Penicillins Against\n            <i>Neisseria gonorrhoeae<\/i>\n            : Comparisons of Strains from Patients with Uncomplicated Infections and from Women with Pelvic Inflammatory Disease"],"prefix":"10.1128","volume":"12","author":[{"given":"Stephen G.","family":"Sackel","sequence":"first","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Alpert","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Rosner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"McCormack","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Departments of Medical Microbiology and Medicine, Boston City Hospital, Boston, Massachusetts 02118,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Finland","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.31","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:03Z","timestamp":1645485243000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.1.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7]]}},"alternative-id":["10.1128\/AAC.12.1.31"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.1.31","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,7]]},"assertion":[{"value":"1977-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}