{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T22:13:39Z","timestamp":1726438419274},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>\n            The streptovaricin complex (SvCx) and rifamycin SV derivatives display potent antiviral activity against the polycythemic strain of Friend leukemia virus (FV-P), as measured by a reduction in the number of spleen foci produced in mice. Such reductions may be explained by inactivation of functions of (i) the spleen focus-forming virus (SFFV), (ii) its \u201chelper\u201d murine leukemia virus (MuLV), or (iii) both viruses normally present in FV-P. We noted that preincubation of FV-P with fractionation products of SvCx, or derivatives of rifamycin SV, at low concentrations (3 to 5 \u03bcg\/ml) reduces the number of spleen foci 80 to 97%, whereas titers of MuLV (from the same inoculum) remain unaffected (MuLV titers were measured by XC, S\n            <jats:sup>+<\/jats:sup>\n            L\n            <jats:sup>\u2212<\/jats:sup>\n            , and \u201chelper activity\u201d assays). Our findings indicate a remarkable biological selectivity of ansamycins, as well as nonansamycin components of SvCx, against the transforming and defective spleen focus-forming virus as compared to MuLV. Thus, the drugs might be useful in distinguishing other types of oncornaviruses.\n          <\/jats:p>","DOI":"10.1128\/aac.12.1.4","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T19:57:02Z","timestamp":1340827022000},"page":"4-10","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Differential Susceptibility of Spleen Focus-Forming Virus and Murine Leukemia Viruses to Ansamycin Antibiotics"],"prefix":"10.1128","volume":"12","author":[{"given":"Julius S.","family":"Horoszewicz","sequence":"first","affiliation":[{"name":"Department of Medical Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Medical Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Medical Viral Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:14:07Z","timestamp":1645467247000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.1.4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7]]}},"alternative-id":["10.1128\/AAC.12.1.4"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.1.4","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[1977,7]]},"assertion":[{"value":"1977-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}