{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:15:06Z","timestamp":1767665706322},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>\n            Cefuroxime, a new parenteral cephalosporin was compared with cephalothin by broth microdilution susceptibility testing against 5,887 routine clinical bacterial isolates in four large clinical laboratories. The minimal inhibitory concentrations (MICs) of cefuroxime against the\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            were consistently lower than those of cephalothin. This was most striking among the\n            <jats:italic>Enterobacter<\/jats:italic>\n            species, which were generally susceptible to cefuroxime (MIC \u2264 8 \u03bcg\/ml), but resistant to cephalothin. Similar results occurred with\n            <jats:italic>Haemophilus<\/jats:italic>\n            species,\n            <jats:italic>Acinetobacter anitratus<\/jats:italic>\n            , meningococci, and\n            <jats:italic>Aeromonas hydrophilia<\/jats:italic>\n            , but\n            <jats:italic>Pseudomonas<\/jats:italic>\n            species and enterococci were resistant to high concentrations of both drugs. Streptococci showed slightly greater susceptibility to cefuroxime than to cephalothin. By contrast, staphylococci were more susceptible to cephalothin.\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            was resistant to cefuroxime, but other anaerobes were generally susceptible.\n          <\/jats:p>","DOI":"10.1128\/aac.12.1.47","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"47-50","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Cefuroxime, a New Parenteral Cephalosporin: Collaborative In Vitro Susceptibility Comparison with Cephalothin Against 5,887 Clinical Bacterial Isolates"],"prefix":"10.1128","volume":"12","author":[{"given":"Ronald N.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Pathology, Kaiser Foundation Hospital Laboratories, Portland, Oregon 97217"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Vincent Hospital, Portland, Oregon 97225"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Gavan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Cleveland Clinic Foundation, Cleveland, Ohio 44106"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Hugh","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, St. Francis Hospital, Wichita, Kansas 67201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Barry","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, University of California (Davis), Sacramento Medical Center, Sacramento, California 95817"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde","family":"Thornsberry","sequence":"additional","affiliation":[{"name":"Antimicrobic Investigation Section, Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.47","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.47","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:12Z","timestamp":1645485252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.1.47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7]]}},"alternative-id":["10.1128\/AAC.12.1.47"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.1.47","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,7]]},"assertion":[{"value":"1977-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}