{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:24:06Z","timestamp":1773030246466,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>\n            This investigation was undertaken to determine whether either\n            <jats:italic>d<\/jats:italic>\n            -primaquine or\n            <jats:italic>l<\/jats:italic>\n            -primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with\n            <jats:italic>Plasmodium vivax<\/jats:italic>\n            . It was found: (i) that the capacities of the isomers and the racemate to cure infections with\n            <jats:italic>Plasmodium cynomolgi<\/jats:italic>\n            in rhesus monkeys were essentially identical; (ii) that the subacute toxicities of the isomers and racemate for this monkey were qualitatively the same, but that\n            <jats:italic>l<\/jats:italic>\n            -primaquine was three to five times as toxic as\n            <jats:italic>d<\/jats:italic>\n            -primaquine and at least twice as toxic as primaquine; and (iii) that the acute single-dose toxicities of the isomers for mice were not only qualitatively different, but that the\n            <jats:italic>d<\/jats:italic>\n            isomer was at least four times as toxic as\n            <jats:italic>l<\/jats:italic>\n            -primaquine. Since previous appraisals of curative activity and tolerability of 8-aminoquinolines in rhesus monkeys have correlated well with appraisals in human volunteers, attention was focused on results acquired with these test subjects. The relevant evaluations showed that\n            <jats:italic>d<\/jats:italic>\n            -primaquine had a therapeutic index at least twice that of primaquine. If this advantage carries over to man, problems that now complicate routine use of primaquine might be obviated. Therefore, a critical comparison of\n            <jats:italic>d<\/jats:italic>\n            -primaquine and primaquine in human volunteers seems indicated.\n          <\/jats:p>","DOI":"10.1128\/aac.12.1.51","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its\n            <i>d<\/i>\n            and\n            <i>l<\/i>\n            Isomers"],"prefix":"10.1128","volume":"12","author":[{"given":"L. H.","family":"Schmidt","sequence":"first","affiliation":[{"name":"The Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Alexander","sequence":"additional","affiliation":[{"name":"The Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Allen","sequence":"additional","affiliation":[{"name":"The Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Rasco","sequence":"additional","affiliation":[{"name":"The Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","updated-by":[{"DOI":"10.1128\/aac.12.5.647-b","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1977,11,1]],"date-time":"1977-11-01T00:00:00Z","timestamp":247190400000}}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.51","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.1.51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:14Z","timestamp":1645485254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.1.51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7]]}},"alternative-id":["10.1128\/AAC.12.1.51"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.1.51","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,7]]},"assertion":[{"value":"1977-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}