{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T07:57:36Z","timestamp":1649059056762},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1977,9,1]],"date-time":"1977-09-01T00:00:00Z","timestamp":241920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,9]]},"abstract":"<jats:p>\n            Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5\u2032-triphosphate to less than 10% of the initial values within 2 min of addition. Accumulation of thymidine, uridine, glutamine, and proline was also inhibited. A gradual efflux of K\n            <jats:sup>+<\/jats:sup>\n            was observed, but the lethal effects of morganocin 174 could not be prevented by maintaining a high K\n            <jats:sup>+<\/jats:sup>\n            or Mg\n            <jats:sup>2+<\/jats:sup>\n            concentration. The Mor174 plasmid codes for an immunity substance that protects cells against the effect of morganocin 174.\n          <\/jats:p>","DOI":"10.1128\/aac.12.3.395","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"395-400","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Mode of Action of Morganocin 174"],"prefix":"10.1128","volume":"12","author":[{"given":"J. A.","family":"Williams","sequence":"first","affiliation":[{"name":"Microbial Genetics Unit, South African Medical Research Council, Department of Microbiology, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krizsanovich-Williams","sequence":"additional","affiliation":[{"name":"Microbial Genetics Unit, South African Medical Research Council, Department of Microbiology, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.3.395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.3.395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:48Z","timestamp":1645485288000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.3.395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,9]]}},"alternative-id":["10.1128\/AAC.12.3.395"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.3.395","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,9]]},"assertion":[{"value":"1977-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}