{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:00:15Z","timestamp":1744164015965},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1977,10,1]],"date-time":"1977-10-01T00:00:00Z","timestamp":244512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>\n            Intraperitoneal injections of 250 mg of ampicillin per kg every 6 h for 30 h sterilized the blood and cerebrospinal fluid of infant rats infected with either a \u03b2-lactamase-containing strain of\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            type b or a strain lacking the enzyme. However, a single injection of 100 mg\/kg sterilized the blood and cerebrospinal fluid of significantly fewer of those rats infected with the \u03b2-lactamase-producing strain. The results suggest that resistance of \u03b2-lactamase-containing strains of\n            <jats:italic>H. influenzae<\/jats:italic>\n            in vivo may be inoculum dependent, as demonstrated previously in vitro. The infant rat model appears suited for the quantitative delineation of the effect of \u03b2-lactamase on the treatment of\n            <jats:italic>H. influenzae<\/jats:italic>\n            bacteremia and meningitis with \u03b2-lactamase antibiotics.\n          <\/jats:p>","DOI":"10.1128\/aac.12.4.461","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"461-464","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Beta-Lactamase Effect on Ampicillin Treatment of\n            <i>Haemophilus influenzae<\/i>\n            B Bacteremia and Meningitis in Infant Rats"],"prefix":"10.1128","volume":"12","author":[{"given":"E. Richard","family":"Moxon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antone A.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.4.461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.4.461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:15:03Z","timestamp":1645485303000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.4.461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,10]]}},"alternative-id":["10.1128\/AAC.12.4.461"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.4.461","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,10]]},"assertion":[{"value":"1977-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}