{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:19:47Z","timestamp":1767665987149},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1977,11,1]],"date-time":"1977-11-01T00:00:00Z","timestamp":247190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p>\n            Amikacin (15 mg\/kg per day) was used in combination with cephalothin (7 g\/m\n            <jats:sup>2<\/jats:sup>\n            per day) as an empiric regimen for de novo febrile (&gt;101\u00b0F [38.3\u00b0C]) episodes in 93 granulocytopenic (&lt;1,000\/mm\n            <jats:sup>3<\/jats:sup>\n            ) cancer patients. Both drugs were given intravenously in four equal doses every 6 h. The response rate for all documented infections was 83%, including 11 of 17 (65%) bacteremias.\n            <jats:italic>Escherichia coli<\/jats:italic>\n            (14 cases) was the most common pathogen, whereas\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            (2 cases) caused fewer infections. Mean amikacin serum levels were 8.7 \u03bcg\/ml at 1 h and 2.2 \u03bcg\/ml at 5 h. Failure of bone marrow recovery in association with a bacteremia was a bad prognostic sign (only two of eight improving). Ototoxicity occurred in two (2%) patients, whereas presumed antibiotic-induced nephrotoxicity developed in six (7%) patients. Surveillance cultures (nose, gums axilla, and rectum) of all hospitalized patients revealed no significant change in the incidence of amikacin resistance. The combination of amikacin and cephalothin in this dose and schedule was safe and efficacious in these granulocytopenic patients.\n          <\/jats:p>","DOI":"10.1128\/aac.12.5.618","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"618-624","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Amikacin and Cephalothin: Empiric Regimen for Granulocytopenic Cancer Patients"],"prefix":"10.1128","volume":"12","author":[{"given":"Davis M.","family":"Hahn","sequence":"first","affiliation":[{"name":"Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute, University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C,","family":"Schimpff","sequence":"additional","affiliation":[{"name":"Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute, University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola Mae","family":"Young","sequence":"additional","affiliation":[{"name":"Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute, University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarence L.","family":"Fortner","sequence":"additional","affiliation":[{"name":"Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute, University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold C.","family":"Standiford","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Baltimore Veteran's Administration Hospital, Baltimore, Maryland 21218"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[{"name":"Clinical Oncology Branch, Baltimore Cancer Research Center, National Cancer Institute, University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.5.618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.12.5.618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:14:24Z","timestamp":1645485264000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.12.5.618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,11]]}},"alternative-id":["10.1128\/AAC.12.5.618"],"URL":"https:\/\/doi.org\/10.1128\/aac.12.5.618","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11]]},"assertion":[{"value":"1977-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}