{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:02:04Z","timestamp":1777532524098,"version":"3.51.4"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1978,4,1]],"date-time":"1978-04-01T00:00:00Z","timestamp":260236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:p>\n            The in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other \u03b2-lactam compounds. Cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 \u03bcg or less per ml, and staphylococci were inhibited by 1.6 \u03bcg or less per ml. Enterococci were relatively resistant. Cefuroxime inhibited \u03b2-lactamase-producing\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            and\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            . Cefuroxime had excellent activity against members of the\n            <jats:italic>Enterobacteriaceae;<\/jats:italic>\n            83% of \u03b2-lactamase-producing\n            <jats:italic>Escherichea coli<\/jats:italic>\n            , 100% of\n            <jats:italic>Salmonella<\/jats:italic>\n            , 100% of\n            <jats:italic>Klebsiella<\/jats:italic>\n            , 90% of\n            <jats:italic>Proteus mirabilis<\/jats:italic>\n            , 95% of\n            <jats:italic>Citrobacter<\/jats:italic>\n            , 56% of\n            <jats:italic>Enterobacter<\/jats:italic>\n            , and 58% of\n            <jats:italic>Shigella<\/jats:italic>\n            were inhibited by 12.5 \u03bcg\/ml. Cefuroxime had activity comparable to that of cefamandole and cefoxitin; it inhibited isolates of\n            <jats:italic>E. coli<\/jats:italic>\n            and\n            <jats:italic>Klebsiella<\/jats:italic>\n            resistant to cefamandole and inhibited\n            <jats:italic>Enterobacter<\/jats:italic>\n            and\n            <jats:italic>Citrobacter<\/jats:italic>\n            resistant to cefoxitin. Many isolates of\n            <jats:italic>Serratia<\/jats:italic>\n            , some indole-positive strains of\n            <jats:italic>Proteus<\/jats:italic>\n            , and\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            were resistant to cefuroxime. Resistance of cefuroxime to hydrolysis by \u03b2-lactamases played a major role in its activity against both gram-positive and gram-negative organisms.\n          <\/jats:p>","DOI":"10.1128\/aac.13.4.657","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Cefuroxime, a Beta-Lactamase-Resistant Cephalosporin with a Broad Spectrum of Gram-Positive and -Negative Activity"],"prefix":"10.1128","volume":"13","author":[{"given":"Harold C.","family":"Neu","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwung P.","family":"Fu","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.4.657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.4.657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:03:16Z","timestamp":1645452196000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.13.4.657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1128\/AAC.13.4.657"],"URL":"https:\/\/doi.org\/10.1128\/aac.13.4.657","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4]]},"assertion":[{"value":"1978-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}