{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:46:58Z","timestamp":1762375618545},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1978,6,1]],"date-time":"1978-06-01T00:00:00Z","timestamp":265507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:p>\n            During a 20-month period all acute nonlymphocytic patients (87 patient trials) receiving cytotoxic chemotherapy were placed on an oral nonabsorbable antibiotic regimen consisting of gentamicin, vancomycin, and nystatin in addition to an intensive program of infection prevention aimed at reducing exogenously acquired and body-surface potential pathogens. Although side effects of anorexia, diarrhea, and nausea were common, gentamicin-vancomycin-nystatin was ingested 80% of the study time. Microbial growth in gingival and rectal cultures was substantially reduced. The incidence of bacteremias and other serious infections was low.\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            , other gram-negative bacilli, and\n            <jats:italic>Candida<\/jats:italic>\n            species caused few infections along the alimentary canal, whereas infections of the skin (especially\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            ) were not reduced compared with those occurring in former years. A total of the 104 acquired gram-negative bacilli were gentamicin resistant; 5 subsequently caused infection. Thus, despite certain definite drawbacks, the use of oral nonabsorbable antibiotics to suppress alimentary tract microbial flora in combination with other infection prevention techniques in granulocytopenic cancer patients has proven feasible and tolerable and has been associated with a low order of life-threatening infections.\n          <\/jats:p>","DOI":"10.1128\/aac.13.6.958","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"958-964","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Infection in Acute Leukemia Patients Receiving Oral Nonabsorbable Antibiotics"],"prefix":"10.1128","volume":"13","author":[{"given":"Davis M.","family":"Hahn","sequence":"first","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Schimpff","sequence":"additional","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarence L.","family":"Fortner","sequence":"additional","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Collier","family":"Smyth","sequence":"additional","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola Mae","family":"Young","sequence":"additional","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[{"name":"Baltimore Cancer Research Center, National Cancer Institute at the University of Maryland Hospital, Baltimore, Maryland 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.6.958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.13.6.958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:16:28Z","timestamp":1645485388000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.13.6.958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,6]]}},"alternative-id":["10.1128\/AAC.13.6.958"],"URL":"https:\/\/doi.org\/10.1128\/aac.13.6.958","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6]]},"assertion":[{"value":"1978-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}