{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:10:47Z","timestamp":1789683047538,"version":"4.0.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1978,7,1]],"date-time":"1978-07-01T00:00:00Z","timestamp":268099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,7]]},"abstract":"<jats:p>\n                    Extracts of two species of marine algae,\n                    <jats:italic>Constantinea simplex<\/jats:italic>\n                    and\n                    <jats:italic>Farlowia mollis<\/jats:italic>\n                    , were tested for antiviral activity in tissue culture and in experimental infections of mice. Treatment of confluent mouse embryo fibroblast cell monolayers with either compound before viral inoculation was effective in inhibiting the replication of herpes simplex virus type 1 and type 2, vaccinia virus, and vesicular stomatitis virus, but not encephalomyocarditis virus, Semliki Forest virus, or murine cytomegalovirus. Prophylactic administration of these extracts was effective in reducing final mortality or prolonging the mean day of death of animals inoculated by the intraperitoneal, intracerebral, or intranasal routes with herpes simplex virus type 2. When therapy was initiated after viral inoculation or at a site other than that of viral inoculation, no significant effect on mortality or on mean day of death was observed. Neither preparation was effective in mice inoculated intraperitoneally with encephalomyocarditis virus, Semliki Forest virus, or murine cytomegalovirus or in animals infected intravaginally with herpes simplex virus type 2. The prophylactic but not therapeutic antiviral activity of these preparations seriously limits their potential use in human herpes simplex virus infections.\n                  <\/jats:p>","DOI":"10.1128\/aac.14.1.24","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T19:57:02Z","timestamp":1340827022000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Antiviral Activity of Extracts from Marine Algae"],"prefix":"10.1128","volume":"14","author":[{"given":"James T.","family":"Richards","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84132,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl R.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84132,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell A.","family":"Glasgow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84132,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James C.","family":"Overall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah College of Medicine, Salt Lake City, Utah 84132,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Frank","family":"Deign","sequence":"additional","affiliation":[{"name":"Naval Biosciences Laboratory, School of Public Health, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin T.","family":"Hatch","sequence":"additional","affiliation":[{"name":"Naval Biosciences Laboratory, School of Public Health, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.1.24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:15:38Z","timestamp":1645467338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.14.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7]]}},"alternative-id":["10.1128\/AAC.14.1.24"],"URL":"https:\/\/doi.org\/10.1128\/aac.14.1.24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7]]},"assertion":[{"value":"1978-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}