{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:44:16Z","timestamp":1791531856537,"version":"4.3.4"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1978,9,1]],"date-time":"1978-09-01T00:00:00Z","timestamp":273456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,9]]},"abstract":"<jats:p>\n            CP-45,899 {3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 4,4-dioxide, [2S-(2\u03b1,5\u03b1)]} is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. In the presence of low concentrations of CP-45,899, ampicillin and other \u03b2-lactams readily inhibit the growth of a variety of resistant bacteria that contain \u03b2-lactamases. CP-45,899 used alone displays only weak antibacterial activity, with the notable exception of its potent effects on susceptible and resistant strains of\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            . CP-45,899 appears to be somewhat less potent but markedly more stable (in aqueous solution) than the recently described \u03b2-lactamase inhibitor clavulanic acid. The spectrum extensions provided by the two compounds are similar. A 1:1 mixture of CP-45,899 and ampicillin displays marked antimicrobial activity in mice experimentally infected with ampicillin-resistant\n            <jats:italic>Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae<\/jats:italic>\n            , and\n            <jats:italic>Proteus vulgaris<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.14.3.414","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":291,"title":["CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization"],"prefix":"10.1128","volume":"14","author":[{"given":"Arthur R.","family":"English","sequence":"first","affiliation":[{"name":"Central Research Division, Pfizer, Inc., Groton, Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Retsema","sequence":"additional","affiliation":[{"name":"Central Research Division, Pfizer, Inc., Groton, Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur E.","family":"Girard","sequence":"additional","affiliation":[{"name":"Central Research Division, Pfizer, Inc., Groton, Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Central Research Division, Pfizer, Inc., Groton, Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne E.","family":"Barth","sequence":"additional","affiliation":[{"name":"Central Research Division, Pfizer, Inc., Groton, Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.3.414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.3.414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:16:33Z","timestamp":1645485393000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.14.3.414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,9]]}},"alternative-id":["10.1128\/AAC.14.3.414"],"URL":"https:\/\/doi.org\/10.1128\/aac.14.3.414","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,9]]},"assertion":[{"value":"1978-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}