{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:51:20Z","timestamp":1758631880320},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1978,11,1]],"date-time":"1978-11-01T00:00:00Z","timestamp":278726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:p>\n            Although ampicillin has been suggested as a useful agent for the treatment of nocardiosis in man, little is known regarding the presence of beta-lactamase in\n            <jats:italic>Nocardia<\/jats:italic>\n            or its possible role in determining resistance to ampicillin and the other beta-lactam antibiotics. We have evaluated 55 isolates of\n            <jats:italic>Nocardia<\/jats:italic>\n            for susceptibility to five beta-lactam antibiotics and for the presence of beta-lactamase.\n            <jats:italic>Nocardia<\/jats:italic>\n            were resistant to penicillin G, cloxacillin, and cefazolin, but 27 and 62% were susceptible to 3.1 and 25 \u03bcg of ampicillin per ml, respectively. Almost 90% of these ampicillin-susceptible or intermediate strains were also susceptible to carbenicillin. The combination of ampicillin and cloxacillin was synergistic against many ampicillin-resistant strains. Beta-lactamase was detected in 89% of\n            <jats:italic>Nocardia<\/jats:italic>\n            isolates when intact cells were used and in six of six strains after cell fractionation. This beta-lactamase was most active against penicillin G and ampicillin, with lesser activity against carbenicillin and cephaloridine. These studies suggest that beta-lactamase may be present in all clinical isolates of\n            <jats:italic>Nocardia<\/jats:italic>\n            and that mechanisms of antimicrobial resistance other than or in addition to beta-lactamase are responsible for resistance of\n            <jats:italic>Nocardia<\/jats:italic>\n            to ampicillin and carbenicillin.\n          <\/jats:p>","DOI":"10.1128\/aac.14.5.704","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"704-709","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Beta-Lactamase Production and Resistance to Beta-Lactam Antibiotics in\n            <i>Nocardia<\/i>"],"prefix":"10.1128","volume":"14","author":[{"suffix":"Jr.","given":"Richard J.","family":"Wallace","sequence":"first","affiliation":[{"name":"Infectious Disease Service, Jefferson Davis Hospital, Baylor College of Medicine, Houston, Texas 77030"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas 77030"},{"name":"Department of Microbiology, and Immunology, Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Vance","sequence":"additional","affiliation":[{"name":"Houston City Health Department, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Weissfeld","sequence":"additional","affiliation":[{"name":"Department of Microbiology, and Immunology, Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Russell","family":"Martin","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Jefferson Davis Hospital, Baylor College of Medicine, Houston, Texas 77030"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas 77030"},{"name":"Department of Microbiology, and Immunology, Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.5.704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.14.5.704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:15:58Z","timestamp":1645485358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.14.5.704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,11]]}},"alternative-id":["10.1128\/AAC.14.5.704"],"URL":"https:\/\/doi.org\/10.1128\/aac.14.5.704","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,11]]},"assertion":[{"value":"1978-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}