{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:18:44Z","timestamp":1762521524338},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>\n            Thirteen independent isolates of\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            associated with nosocomial urinary tract infections were obtained from the clinical microbiology laboratory at Hines Veterans Administration Hospital. The isolates were resistant to at least ampicillin, carbenicillin, gentamicin, and tobramycin. They could be divided into two groups on the basis of their antibiotypes. Group I (9 strains) showed resistance to 13 antibiotics, including 3 beta-lactams, 6 aminoglycosides, tetracycline, sulfonamide, trimethoprim, and polymyxin B. Group II (4 strains) was resistant to 11 antibiotics, including 3 beta-lactams, 5 aminoglycosides, sulfonamide, trimethoprim, and polymyxin B. Donors from both groups transferred resistance traits to\n            <jats:italic>Escherichia coli<\/jats:italic>\n            . Transconjugants from matings with group II donors all acquired resistance to nine antibiotics, including the three beta-lactams, five aminoglycosides, and sulfonamide. Transconjugants from matings with group I donors were of varied antibiotypes, inheriting resistance to up to 11 of the 13 antibiotics. Resistances to trimethoprim and polymyxin B were never observed to transfer.\n            <jats:italic>E. coli<\/jats:italic>\n            transconjugants of each group were capable of transferring multiple-antibiotic resistance to several other members of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            . All group II\n            <jats:italic>S. marcescens<\/jats:italic>\n            and\n            <jats:italic>E. coli<\/jats:italic>\n            donors and all group I\n            <jats:italic>S. marcescens<\/jats:italic>\n            donors transferred carbenicillin, streptomycin, kanamycin, gentamicin, tobramycin, and sisomicin resistance to\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            . The results suggest that these\n            <jats:italic>S. marcescens<\/jats:italic>\n            strains harbor R factors of a broader host range than previously reported.\n          <\/jats:p>","DOI":"10.1128\/aac.15.1.93","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"93-100","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Hospital Isolates of\n            <i>Serratia marcescens<\/i>\n            Transferring Ampicillin, Carbenicillin, and Gentamicin Resistance to Other Gram-Negative Bacteria Including\n            <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"15","author":[{"given":"Vera M.","family":"Olexy","sequence":"first","affiliation":[{"name":"Infectious Disease Laboratory Hines V. A. Hospital, Hines, Illinois 60141"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Bird","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory Hines V. A. Hospital, Hines, Illinois 60141"},{"name":"Clinical Microbiology Laboratory, Hines V. A. Hospital, Hines, Illinois 60141"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans G.","family":"Grieble","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory Hines V. A. Hospital, Hines, Illinois 60141"},{"name":"Department of Medicine Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K.","family":"Farrand","sequence":"additional","affiliation":[{"name":"Infectious Disease Laboratory Hines V. A. Hospital, Hines, Illinois 60141"},{"name":"Department of Microbiology, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.15.1.93","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.15.1.93","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:07:41Z","timestamp":1645452461000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.15.1.93"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1128\/AAC.15.1.93"],"URL":"https:\/\/doi.org\/10.1128\/aac.15.1.93","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]},"assertion":[{"value":"1979-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}