{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:30:16Z","timestamp":1775230216356,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1979,2,1]],"date-time":"1979-02-01T00:00:00Z","timestamp":286675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>\n            Of 49 compounds known to have antitumor properties, 6 were found to have significant activity against\n            <jats:italic>Trypanosoma rhodesiense<\/jats:italic>\n            infections in mice. Activity against the African trypanosomes has not been reported previously for any of these six compounds. In order of decreasing activity these compounds were: (i) imidazole-4-carboxamide, 5-(3,3-dimethyl-1,1-triazene), (ii) inosine diglycolaldehyde, (iii)\n            <jats:italic>cis<\/jats:italic>\n            -diamminedichloro-platinum, (iv) streptozotocin, (v) coralyne sulfate, and (vi) 5-fluoro-2\u2032-deoxyuridine. The percentage of \u201chits\u201d (12.2%) from these known antitumor agents was approximately twice as great as when other means are employed for the selection of compounds for this test system.\n          <\/jats:p>","DOI":"10.1128\/aac.15.2.157","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"157-160","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["Activity of Antitumor Drugs Against African Trypanosomes"],"prefix":"10.1128","volume":"15","author":[{"given":"Kenneth E.","family":"Kinnamon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar A.","family":"Steck","sequence":"additional","affiliation":[{"name":"Division of Medical Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora S.","family":"Rane","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine, Medical Research Annex, Miami, Florida 33142"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.15.2.157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.15.2.157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:16:19Z","timestamp":1645485379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.15.2.157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1128\/AAC.15.2.157"],"URL":"https:\/\/doi.org\/10.1128\/aac.15.2.157","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2]]},"assertion":[{"value":"1979-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}