{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:23:43Z","timestamp":1759991023676},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1979,7,1]],"date-time":"1979-07-01T00:00:00Z","timestamp":299635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1979,7]]},"abstract":"<jats:p>Investigation of two infants suggested that peak ventricular fluid levels of chloramphenicol after intravenous administration were achieved after 3 h. The penetration of chloramphenicol into ventricular fluid may be unpredictable. In one patient, the peak ventricular fluid level was 57.5% of the peak serum level, and it was only 22.5% in the other patient. This observation may explain some of the past treatment failures when chloramphenicol was utilized in patients with gram-negative ventriculitis and meningitis.<\/jats:p>","DOI":"10.1128\/aac.16.1.7","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"7-8","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Ventricular Fluid Levels of Chloramphenicol in Infants"],"prefix":"10.1128","volume":"16","author":[{"given":"Ram","family":"Yogev","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, The Children's Memorial Hospital, Chicago, Illinois 60614"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, The Children's Memorial Hospital, Chicago, Illinois 60614"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.16.1.7","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.16.1.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:15:26Z","timestamp":1645485326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.16.1.7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,7]]}},"alternative-id":["10.1128\/AAC.16.1.7"],"URL":"https:\/\/doi.org\/10.1128\/aac.16.1.7","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,7]]},"assertion":[{"value":"1979-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}