{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:09:16Z","timestamp":1761059356543},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p>Ro 13-9904 is a new cephalosporin antibiotic with a wide spectrum of activity similar to that of cefotaxime and some other newer beta-lactam compounds. In the present study, the response to Ro 13-9904 of 13 strains of enterobacteria, selected on the basis of differential patterns of susceptibility to beta-lactam agents, was investigated. The new cephalosporin displayed high intrinsic activity against most of the enterobacteria tested, but a group of Klebsiella and Hafnia alvei strains was identified against which Ro 13-9904 (and cefotaxime) exhibited reduced activity. Investigation of these strains revealed several different types of response to Ro 13-9904 and cefotaxime. Although such \"difficult\" strains represent a small minority of clinical isolates, it is likely that it is this group of strains against which the new generation of highly potent, broad-spectrum beta-lactam antibiotics will display significant differential activity.<\/jats:p>","DOI":"10.1128\/aac.19.1.66","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:03:40Z","timestamp":1340841820000},"page":"66-71","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Activity of a new cephalosporin antibiotic, Ro 13-9904 against dense populations of selected enterobacteria"],"prefix":"10.1128","volume":"19","author":[{"given":"D","family":"Greenwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Eley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.19.1.66","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.19.1.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:02:34Z","timestamp":1645452154000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.19.1.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1128\/AAC.19.1.66"],"URL":"https:\/\/doi.org\/10.1128\/aac.19.1.66","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]},"assertion":[{"value":"1981-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}