{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:08:32Z","timestamp":1648840112746},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1972,7,1]],"date-time":"1972-07-01T00:00:00Z","timestamp":78796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1972,7]]},"abstract":"<jats:p>\n            Ampicillin and tetracycline, in doses of 2 g a day, were compared in the treatment of acute exacerbations of chronic bronchitis. Seventy-nine patients were followed for 3 to 29 months and were treated for 118 exacerbations. Clinical improvement occurred after 10 days of treatment with either drug in over 80% of the cases.\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            and\n            <jats:italic>Diplococcus pneumoniae<\/jats:italic>\n            were eradicated from the sputum more than 60% of the time, but in general there was a poor correlation between bacteriological clearing and clinical response. The effect of chemoprophylaxis with ampicillin and tetracycline in doses of 1 g a day on the frequency of acute exacerbations of bronchitis was compared with that of a placebo. Seven hundred eighty prophylactic regimens, consisting of one capsule every 12 hr for 5 days beginning with the first sign of a cold, were prescribed for 76 patients. Irrespective of the regimen, an acute exacerbation of bronchitis was encountered at approximately 13% of the follow-up visits to the clinic.\n          <\/jats:p>","DOI":"10.1128\/aac.2.1.45","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"45-48","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Ampicillin and Tetracycline in the Treatment and Prophylaxis of Chronic Bronchitis"],"prefix":"10.1128","volume":"2","author":[{"given":"H. H.","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. K.","family":"Avent","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"Counts","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. N.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington and Harborview Medical Center, Seattle, Washington 98104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.2.1.45","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.2.1.45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:05:57Z","timestamp":1645484757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.2.1.45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,7]]}},"alternative-id":["10.1128\/AAC.2.1.45"],"URL":"https:\/\/doi.org\/10.1128\/aac.2.1.45","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,7]]},"assertion":[{"value":"1972-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}