{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:14:13Z","timestamp":1770336853432,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1981,11,1]],"date-time":"1981-11-01T00:00:00Z","timestamp":373420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1981,11]]},"abstract":"\n Several new beta-lactam antimicrobial agents have been introduced in the last few years. In this investigation, the in vitro activities of several recently introduced cephalosporins (cefoperazone, cefotaxime, ceftazidime, and ceftizoxime), moxalactam, and\n N<\/jats:italic>\n -formimidoyl thienamycin were compared with those of cefoxitin, clindamycin, and metronidazole against 203 strains of anaerobic bacteria. At achievable serum levels, all of the antimicrobial agents were active against essentially 100% of the strains of anaerobic gram-positive cocci,\n Clostridium perfringens, Leptotrichia buccalis<\/jats:italic>\n , and species of\n Selenomonas, Veillonella<\/jats:italic>\n , and\n Eubacterium<\/jats:italic>\n . Clindamycin, metronidazole, and\n N<\/jats:italic>\n -formimidoyl thienamycin were the most active agents against the\n Bacteroides fragilis<\/jats:italic>\n group, inhibiting all strains at concentrations which can be achieved in serum. Of the remaining agents tested against the\n B. fragilis<\/jats:italic>\n group, cefoxitin (which required 64 \u03bcg\/ml to inhibit 90% of the strains) was the most active, followed by cefoperazone (128 \u03bcg\/ml), cefotaxime (128 \u03bcg\/ml), moxalactam (128 \u03bcg\/ml), ceftizoxime (256 \u03bcg\/ml), and ceftazidime (>256 \u03bcg\/ml). Important differences in cephalosporin susceptibility among species of the\n B. fragilis<\/jats:italic>\n group were observed. Metronidazole and\n N<\/jats:italic>\n -formimidoyl thienamycin were the most active drugs against species of clostridia other than\n C. perfringens<\/jats:italic>\n ; the other antibiotics displayed poor activity, although this is partly due to inclusion of a relatively large number of strains of\n Clostridium difficile<\/jats:italic>\n which were very resistant to several of the cephalosporins. Only metronidazole was active against all species of\n Fusobacterium<\/jats:italic>\n . Clindamycin and\n N<\/jats:italic>\n -formimidoyl thienamycin displayed excellent activity against gram-positive, non-spore-forming bacilli, requiring \u22648 \u03bcg\/ml to inhibit 100% of the strains. Ceftazidime, cefoperazone, and moxalactam were bactericidal for 25 strains of\n B. fragilis<\/jats:italic>\n at concentrations equal or close to those required for inhibition. On the basis of its activity in vitro,\n N<\/jats:italic>\n -formimidoyl thienamycin appears to be the most promising of the new beta-lactam antibiotics for the treatment of infections involving anaerobic bacteria.\n <\/jats:p>","DOI":"10.1128\/aac.20.5.600","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:03:40Z","timestamp":1340841820000},"page":"600-609","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Comparative In Vitro Activity of New Beta-Lactam Antibiotics Against Anaerobic Bacteria"],"prefix":"10.1128","volume":"20","author":[{"given":"Rial D.","family":"Rolfe","sequence":"first","affiliation":[{"name":"Research Services, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073"},{"name":"Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney M.","family":"Finegold","sequence":"additional","affiliation":[{"name":"The Medical Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073"},{"name":"Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.20.5.600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.20.5.600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:12:31Z","timestamp":1645452751000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.20.5.600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,11]]}},"alternative-id":["10.1128\/AAC.20.5.600"],"URL":"https:\/\/doi.org\/10.1128\/aac.20.5.600","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11]]},"assertion":[{"value":"1981-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}