{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:09:20Z","timestamp":1757704160962},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1982,4,1]],"date-time":"1982-04-01T00:00:00Z","timestamp":386467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:p>We studied 21 strains of amikacin-resistant Serratia marcescens from three different U.S. cities, Twenty of the 21 strains contained conjugative R plasmids mediating gentamicin and tobramycin resistance. Amikacin-resistant S. marcescens from two cities predominated in protracted outbreaks. Conversely, the amikacin-resistant Charleston strain (serotype 02\/03:nonmotile) was isolated from only four patients during an outbreak of gentamicin- and tobramycin resistant, amikacin-susceptible S. marcescens (serotype O19:O17). Five different representative amikacin-resistant S. marcescens, each containing a single conjugative plasmid, elaborated a nontransferable aminoglycoside (6')-N-acetyltransferase [AAC(6')] with similar substrate profiles in addition to other transferable aminoglycoside-modifying enzymes. One amikacin-resistant S. marcescens cured of its plasmid and another naturally occurring plasmid-free amikacin-resistant S. marcescens elaborated only AAC(6')-1. These data support the concept of a chromosomal locus in S. marcescens for AAC(6')-1 which commonly coexists with plasmid-mediated genes for aminoglycoside-modifying enzymes.<\/jats:p>","DOI":"10.1128\/aac.21.4.587","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:03:40Z","timestamp":1340841820000},"page":"587-591","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens"],"prefix":"10.1128","volume":"21","author":[{"suffix":"Jr","given":"J F","family":"John","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W F","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Kresel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.21.4.587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.21.4.587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:18:04Z","timestamp":1645453084000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.21.4.587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1128\/AAC.21.4.587"],"URL":"https:\/\/doi.org\/10.1128\/aac.21.4.587","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]},"assertion":[{"value":"1982-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}