{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:43:24Z","timestamp":1760204604247},"reference-count":0,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[1988,11,1]],"date-time":"1988-11-01T00:00:00Z","timestamp":594345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:p>The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.<\/jats:p>","DOI":"10.1128\/aac.32.11.1740","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:04:52Z","timestamp":1340841892000},"page":"1740-1741","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers"],"prefix":"10.1128","volume":"32","author":[{"given":"D L","family":"Dworzack","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Allais","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sookpranee","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"W E","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University, Omaha, Nebraska 68178."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.11.1740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.11.1740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:01:20Z","timestamp":1645455680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.32.11.1740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["10.1128\/AAC.32.11.1740"],"URL":"https:\/\/doi.org\/10.1128\/aac.32.11.1740","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]},"assertion":[{"value":"1988-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}