{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:34:49Z","timestamp":1792553689908,"version":"4.5.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:p>Testing of the susceptibility to 12 antimicrobial agents, including beta-lactams, aminoglycosides, ciprofloxacin, and erythromycin, was performed by broth microdilution on 78 consecutive clinical isolates of Nocardia asteroides. Surprisingly, a limited number of patterns of susceptibility were identified that included all drug classes, with 95% of isolates exhibiting one of five patterns. One group (17%) exhibited resistance to the broad-spectrum cephalosporins, one group (18%) was susceptible to both ampicillin and erythromycin, one group (17%) was susceptible to ampicillin and carbenicillin but intermediate in susceptibility to imipenem, and the most common group (35%) was resistant to ampicillin but susceptible to the broad-spectrum cephalosporins and imipenem. The most active parenteral agents were amikacin (95%), imipenem (88%), ceftriaxone (82%), and cefotaxime (82%), while the most active oral agents were the sulfonamides (100%), minocycline (100%), and ampicillin (40%). Additional studies are needed to determine whether differences in beta-lactamases relate to varying beta-lactam resistance and whether taxonomic differences that correlate with the different susceptibility groups can be identified.<\/jats:p>","DOI":"10.1128\/aac.32.12.1776","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:04:52Z","timestamp":1340841892000},"page":"1776-1779","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":217,"title":["Antimicrobial susceptibility patterns of Nocardia asteroides"],"prefix":"10.1128","volume":"32","author":[{"suffix":"Jr","given":"R J","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Texas Health Center, Tyler 75710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L C","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Health Center, Tyler 75710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sumter","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Health Center, Tyler 75710."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Texas Health Center, Tyler 75710."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.12.1776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.12.1776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:01:18Z","timestamp":1645455678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.32.12.1776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1128\/AAC.32.12.1776"],"URL":"https:\/\/doi.org\/10.1128\/aac.32.12.1776","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]},"assertion":[{"value":"1988-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}