{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:59:11Z","timestamp":1758992351756},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p>A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg (500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 micrograms\/ml (range, 0.002 to 0.03 micrograms\/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.<\/jats:p>","DOI":"10.1128\/aac.32.5.723","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:04:52Z","timestamp":1340841892000},"page":"723-725","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid"],"prefix":"10.1128","volume":"32","author":[{"given":"L","family":"Bodhidatta","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chitwarakorn","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kuvanont","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Echeverria","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.5.723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.5.723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:05:07Z","timestamp":1645455907000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.32.5.723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1128\/AAC.32.5.723"],"URL":"https:\/\/doi.org\/10.1128\/aac.32.5.723","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]},"assertion":[{"value":"1988-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}