{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:51:20Z","timestamp":1790855480265,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an inducible beta-lactamase, showed enhanced resistance to newer cephalosporins and aztreonam. This observation suggested that species of Aeromonas, like those of other genera with inducible beta-lactamases, may pose therapeutic problems associated with the rapid development of multiple beta-lactam resistance. Thus, a study was designed to identify the beta-lactamases in 12 strains representing four species of Aeromonas and assess their role in drug resistance. Eleven strains possessed inducible beta-lactamases. One strain showed no detectable activity. An analysis of substrate and inhibitor profiles, isoelectric points, and beta-lactam susceptibility patterns revealed the presence of at least four distinguishable inducible beta-lactamases. These enzymes were involved in the resistance of strains within the genus to penicillins, cephalosporins, aztreonam, and imipenem but not cefoxitin. Unlike most other organisms with inducible beta-lactamases, all four strains of A. caviae, one of four strains of A. sobria, and one of three strains of A. hydrophila possessed two distinct inducible beta-lactamases. Furthermore, substrate and inhibitor profiles revealed that many of these Aeromonas beta-lactamases were distinct from inducible enzymes that have been characterized in other genera of gram-negative bacteria.<\/jats:p>","DOI":"10.1128\/aac.32.9.1314","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:04:52Z","timestamp":1340841892000},"page":"1314-1319","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Beta-lactam resistance in Aeromonas spp. caused by inducible beta-lactamases active against penicillins, cephalosporins, and carbapenems"],"prefix":"10.1128","volume":"32","author":[{"given":"J S","family":"Bakken","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.9.1314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.32.9.1314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:09:21Z","timestamp":1645456161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.32.9.1314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1128\/AAC.32.9.1314"],"URL":"https:\/\/doi.org\/10.1128\/aac.32.9.1314","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]},"assertion":[{"value":"1988-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}