{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:10:57Z","timestamp":1774408257451,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:p>We compared the safety and efficacies of ofloxacin and trimethoprim-sulfamethoxazole for the treatment of acute uncomplicated cystitis in women enrolled in a multicenter study. Data from three centers were combined for this report because the study design and study populations were identical, and patients were enrolled within an 18-month period. Cure rates for evaluable patients 4 weeks after treatment were high for all regimens: ofloxacin (200 mg) twice daily for 3 days, 22 of 25 (88%) cured; ofloxacin (200 mg) twice daily for 7 days, 42 of 49 (86%) cured; ofloxacin (300 mg) twice daily for 7 days, 25 of 25 (100%) cured; and trimethoprim-sulfamethoxazole (160\/800 mg) twice daily for 7 days, 46 of 52 (88%) cured. Ofloxacin was more effective than trimethoprim-sulfamethoxazole in eradicating Escherichia coli from rectal cultures during and 1 week after treatment. Both ofloxacin and trimethoprim-sulfamethoxazole markedly reduced vaginal colonization with E. coli during and 4 weeks after therapy. Emergence of resistant coliforms in rectal flora was found in 5 (19%) of 27 patients treated with trimethoprim-sulfamethoxazole but none of 50 ofloxacin-treated patients who were studied (P = 0.004). Adverse effects were equally common among the four treatment groups. We conclude that 3 to 7 days of ofloxacin is as safe and effective as trimethoprim-sulfamethoxazole for treatment of uncomplicated cystitis in women and that ofloxacin effectively reduces the fecal and vaginal reservoirs of coliforms in such patients.<\/jats:p>","DOI":"10.1128\/aac.33.8.1308","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:04:52Z","timestamp":1340841892000},"page":"1308-1312","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Ofloxacin versus trimethoprim-sulfamethoxazole for treatment of acute cystitis"],"prefix":"10.1128","volume":"33","author":[{"given":"T M","family":"Hooton","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Latham","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E S","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P L","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W E","family":"Stamm","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.33.8.1308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.33.8.1308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:11:46Z","timestamp":1645456306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.33.8.1308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["10.1128\/AAC.33.8.1308"],"URL":"https:\/\/doi.org\/10.1128\/aac.33.8.1308","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8]]},"assertion":[{"value":"1989-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}