{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:16:10Z","timestamp":1792451770038,"version":"4.5.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>We infected mice with arthroconidia of Coccidioides immitis by intraperitoneal injection and 48 h later treated them with either oral fluconazole or SDZ89-485, a new triazole. Both drugs completely inhibited fungal growth when administered at a dose of 50 mg\/kg of body weight twice a day, but only SDZ89-485 was fully inhibitory at a dose of 5 mg\/kg twice a day. In a second experiment, treatment with SDZ89-485 was delayed until 8 days after infection to allow infection to be well established before treatment. Both 5 and 50 mg\/kg twice a day were effective regimens, which establishes that SDZ89-485 has activity against spherules in vivo. Mice that received fluconazole (50 mg\/kg twice a day) had a peak level in blood of 60 micrograms\/ml 1 h after a dose, but no measurable amount was found after 12 h. SDZ89-485 was more slowly absorbed, reaching a peak level in blood of 14 micrograms\/ml at 12 to 15 h after a dose of 50 mg\/kg. We conclude that SDZ89-485 is more effective than fluconazole as treatment for experimental systemic coccidioidomycosis in mice, even though fluconazole achieves higher peak levels in blood.<\/jats:p>","DOI":"10.1128\/aac.34.1.13","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"13-16","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of fluconazole and SDZ89-485 for therapy of experimental murine coccidioidomycosis"],"prefix":"10.1128","volume":"34","author":[{"given":"J","family":"Fierer","sequence":"first","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kirkland","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Finley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.1.13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.1.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:13:03Z","timestamp":1645456383000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.34.1.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1128\/AAC.34.1.13"],"URL":"https:\/\/doi.org\/10.1128\/aac.34.1.13","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]},"assertion":[{"value":"1990-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}