{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:27:44Z","timestamp":1760189264949},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. By contrast 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (FEAU) induced a sustained, although less dramatic, decrease of viral replication without apparent toxic effect. FEAU was also effective when given orally. However, in both cases this inhibitory effect was transient.<\/jats:p>","DOI":"10.1128\/aac.34.3.473","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"473-475","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks"],"prefix":"10.1128","volume":"34","author":[{"given":"I","family":"Fourel","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Hantz","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Jacquet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Chomel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Fox","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Trepo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche sur les H\u00e9patites, le SIDA et les R\u00e9trovirus Humains, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U 271, Lyon, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.3.473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.3.473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:11:21Z","timestamp":1645456281000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.34.3.473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1128\/AAC.34.3.473"],"URL":"https:\/\/doi.org\/10.1128\/aac.34.3.473","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]},"assertion":[{"value":"1990-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}