{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:17Z","timestamp":1787242577369,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1990,6,1]],"date-time":"1990-06-01T00:00:00Z","timestamp":644198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:p>Biliary pseudolithiasis has been reported in patients who received ceftriaxone therapy. To examine this phenomenon further, serial gallbladder sonograms were evaluated in 44 adult patients who received intravenous ceftriaxone at 2 g or a placebo daily for 14 days in a double-blind controlled study. Ultrasound examinations of gallbladders were performed on days 1 and 14 of therapy and 2 weeks posttherapy if abnormalities were observed on day 14. Eight patients were unevaluable because of abnormal base-line gallbladder sonograms. Thirty-six patients (ceftriaxone, n = 28; placebo, n = 8) demonstrated normal baseline gallbladder sonograms and were evaluated for the development of change. A total of 6 of 28 (21.4%) ceftriaxone-treated patients and 1 of 8 (12.5%) patients who received the placebo demonstrated abnormal gallbladder sonograms on day 14 (P = 0.491). Four of the six ceftriaxone-treated patients demonstrating abnormal sonograms were clinically asymptomatic, while two patients reported vomiting. The abnormal sonograms of gallbladders of patients treated with ceftriaxone returned to normal between 9 and 26 days posttherapy. These data suggest an association between ceftriaxone treatment and the development of gallbladder abnormalities on ultrasound examination which resolve spontaneously on discontinuation of ceftriaxone therapy.<\/jats:p>","DOI":"10.1128\/aac.34.6.1146","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T20:05:50Z","timestamp":1340827550000},"page":"1146-1149","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Apparent biliary pseudolithiasis during ceftriaxone therapy"],"prefix":"10.1128","volume":"34","author":[{"given":"K L","family":"Heim-Duthoy","sequence":"first","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Caperton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Matzke","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Enthoven","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.6.1146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.34.6.1146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T10:19:11Z","timestamp":1645438751000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.34.6.1146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,6]]}},"alternative-id":["10.1128\/AAC.34.6.1146"],"URL":"https:\/\/doi.org\/10.1128\/aac.34.6.1146","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6]]},"assertion":[{"value":"1990-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}