{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:12:18Z","timestamp":1790424738988,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>By using an assay system based on a human hepatoblastoma cell line (HB611) that continuously synthesizes hepatitis B virus DNA, the following compounds were found to inhibit hepatitis B virus DNA synthesis at concentrations that were significantly lower than their minimum cytotoxic concentrations: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(phosphonylmethoxyethyl)adenine, 2',3'-dideoxy-2',3'-didehydrocytidine, and 2',3'-dideoxycytidine. The most potent compound was PMEDAP (50% effective concentration, 0.02 micrograms\/ml). The selective index, or ratio of the 50% cytotoxic concentration to 50% effective concentration, of PMEDAP was greater than 750.<\/jats:p>","DOI":"10.1128\/aac.35.2.394","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T20:05:50Z","timestamp":1340827550000},"page":"394-397","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis"],"prefix":"10.1128","volume":"35","author":[{"given":"T","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Clercq","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Fukushima Medical College, Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.2.394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.2.394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T10:16:09Z","timestamp":1645438569000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.35.2.394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1128\/AAC.35.2.394"],"URL":"https:\/\/doi.org\/10.1128\/aac.35.2.394","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]},"assertion":[{"value":"1991-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}