{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:44:24Z","timestamp":1748259864040},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1991,4,1]],"date-time":"1991-04-01T00:00:00Z","timestamp":670464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p>SCH 39304 was tested for treatment of acute or established murine pulmonary blastomycosis and was compared with ketoconazole and fluconazole in a model of acute infection. Only SCH 39304 at 25 or 50 mg\/kg of body weight per day produced 100% survival for 30 days after the 20-day treatment, although only 33% of the mice were cleared of infection. SCH 39304 at 2 mg\/kg\/day was similar to ketoconazole at 100 mg\/kg\/day and to fluconazole at 10 mg\/kg\/day. In a model of established blastomycosis, used to evaluate long-term treatment of very sick or moribund mice, SCH 39304 at 50 mg\/kg\/day protected against death with a 96% cumulative 8-week survival. SCH 39304 was clearly superior on a milligram-per-kilogram basis in acute blastomycosis, and long-term treatment of more severe blastomycosis was curative.<\/jats:p>","DOI":"10.1128\/aac.35.4.788","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T20:05:50Z","timestamp":1340827550000},"page":"788-790","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis"],"prefix":"10.1128","volume":"35","author":[{"given":"E","family":"Brummer","sequence":"first","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L H","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.4.788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.4.788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T10:18:55Z","timestamp":1645438735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.35.4.788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["10.1128\/AAC.35.4.788"],"URL":"https:\/\/doi.org\/10.1128\/aac.35.4.788","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[1991,4]]},"assertion":[{"value":"1991-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}